Prolactin level in women with abnormal uterine bleeding visiting department of obstetrics and gynecology in a university teaching hospital in Ajman, UAE

This study was conducted among women in the reproductive age group with abnormal uterine bleeding [AUB] to determine the pattern of prolactin level. In this study, a total of 400 women in the reproductive age group with AUB attending GMC Hospital were recruited and their prolactin levels were evaluated. Age, marital status, reproductive health history and details of AUB were noted. SPSS version 21 was used for data analysis. Descriptive statistics was performed to describe the population, and inferential statistics such as Chi-square test was performed to find the association between dependent and independent variables. Out of 400 women, 351 [87.8%] were married, 103 [25.8%] were in the age group 25 years or below, 213 [53.3%] were between 26-35 years and 84 [21.0%] were above 35 years. Mean age was 30.3 years with a standard deviation 6.7. The prolactin level ranged between 15.34 mIU/l and 2800 mIU/l. The mean and SD observed were 310 mIU/l and 290 mIU/l respectively. The prolactin level was high among AUB patients with inter-menstrual bleeding compared to other groups. Additionally, the level was high among women with age greater than 25 years compared to those with age less than or equal to 25 years. But the difference observed was not statistically significant. With regard to BMI, 27.3% were obese and 37.5% were overweight. This study showed that as BMI increases, the level of prolactin decreases, with no statistically significant difference. The prolactin level was high in women with inter-menstrual bleeding as compared to those with other abnormal uterine bleeding. High serum prolactin level was observed in 11.3% of participants with oligomenorrhoea, 7.3% with polymenorrhoea, 3.7% with menometrorrhagia, 10.3% with menorrhagia, and 18.9% with inter-menstrual bleeding. But, the difference observed was not statistically significant. There is no statistically significant difference in the mean prolactin levels in AUB patients of different age groups and different BMI groups

Gestational trophoblastic disease in ectopic pregnancy: a case report with review of literature

Gestational trophoblastic disease associated with ectopic pregnancy is a rare event and persistent trophoblastic disease is a well recognized complication of conservative surgical treatment for ectopic pregnancy but rarely secondary trophoblastic implanatation may occur after salpingectomy. This is a case report of a rare and unusual presentation of persistent trophoblastic implantation following salpingectomy for ruptured ectopic pregnancy. The patients was admitted as an emergency with acute abdomen in severely shocked state. She underwent urgent laparotomy with right salpingectomy for ruptured tubal pregnancy with massive haemoperitonium. Postoperative period was smooth but one month following the operation she developed generalized nonspecific symptoms with high serum BHCG titer which was [50000 IU]. Patient had been transferred for the territory trophoblastic disease centre for further follow up. She was kept on combination regimen of chemotherapy. This case presentation was analyzed with other reported case series of the same problem. The analysis of the cases showed that most patients presented with abdominal pain. Some may have vaginal bleeding. Haemoperitonium was the most frequent surgical finding. It is concluded from this case with other previous reported cases that strict histological criteria should be applied for the diagnosis of gestational trophoblastic disease when a sample of ectopic pregnancy is analyzed in addition to careful monitoring and follow up of all cases of ectopic pregnancy with serum Human Chorionic Gonadotrophin after surgical treatment