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Mem. Inst. Oswaldo Cruz ; 101(8): 895-898, Dec. 2006. ilus, graf, tab
Artículo en Inglés | LILACS | ID: lil-440578

RESUMEN

Capillaria hepatica causes two main lesions in the liver of rats: multifocal chronic inflammation, directly related to the presence of disintegrating parasites and their eggs, and a process of systematized septal fibrosis. The comparative behavior of these two lesions was investigated in rats experimentally infected with 600 embryonated eggs, following either corticosteroid treatment or specific antigenic stimulation, in an attempt to understand the relationship between these two lesions, and the pathogenesis of septal fibrosis. The two treatments differently modified the morphological aspects of the focal parasitic-related lesions, but did not interfere with the presentation of diffuse septal fibrosis, although a mild decrease in the degree of fibrosis occurred in corticoid-treated animals. These findings indicate that although the two lesions are C. hepatica induced, they are under different pathogenetic control, the induction of septal fibrosis being triggered during early infection to follow an independent pathway.


Asunto(s)
Animales , Masculino , Femenino , Ratas , Anticuerpos Antihelmínticos/sangre , Antígenos Helmínticos/administración & dosificación , Capillaria/inmunología , Infecciones por Enoplida/parasitología , Cirrosis Hepática Experimental/parasitología , Enfermedad Crónica , Modelos Animales de Enfermedad , Infecciones por Enoplida/tratamiento farmacológico , Infecciones por Enoplida/inmunología , Glucocorticoides/uso terapéutico , Hidroxiprolina/análisis , Cirrosis Hepática Experimental/tratamiento farmacológico , Cirrosis Hepática Experimental/inmunología , Prednisona/uso terapéutico , Ratas Wistar , Índice de Severidad de la Enfermedad
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