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Background: Dengue is a major public-health issue all over tropical and sub-tropical regions of the world. It is the most rapidly spreading mosquito-borne viral disease, which shows a 30-fold increase in global incidence over the past 50 years. According to the estimates from the World Health Organization 50-100 million dengue infections occur each year and that to add to the seriousness that around 50% of the world’s population lives in countries where the disease is endemic.Methods: Educational Interventional cross-sectional study done in 2 selected Govt. Higher Secondary School in Bhopal. 100 students were selected in both school in which 50 boys and 50 girl’s student selected. A pretested, semi-structured questionnaire developed by investigator which comprised of 36 questions. The interviewee who was willing to participate in the study was given the questionnaire and was asked to fill the questionnaire before and after the educational intervention and the results were analyzed.Results: The study involved a total of 100 students who successfully answered all the baseline and follow up questionnaire. A total of 50% male students and 50% female students were present in this study. This study showed of significance increase in knowledge and significance change in their attitude after the post intervention questionnaires.Conclusions: The knowledge about dengue fever was good among students, attitudes towards to keep their surroundings was also good; however, it was found that the good knowledge and attitudes does not necessarily lead to good practice. Health education programme should be continued and intensified with emphasis on school, college students and young adults.
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Objective: Granulosa cell tumors (GCT) are low-grade malignant sex cord-stromal tumors (SCST) with late metastasis/recurrences and long disease-free periods. We performed a clinicopathological evaluation of GCT to ascertain features having prognostic impact. Materials and Methods: All cases of GCT of ovary from January 2006 to December 2018 were assessed for architectural patterns, nuclear grooves, and Call-Exner bodies. Each feature was graded on frequency of occurrence: not present (0)–very frequent (3). Anisonucleosis, necrosis, and inflammation were noted. Cases were grouped on mitotic count; <10 mitosis/10 High power field (HPF) or >=11 mitoses/10 HPF and Ki-67 index; <10% Ki-67 and >=11% Ki-67. Results: GCT formed 60.1% of SCST. Sixty cases' ages were in the range of 15–78 years (median 45). Clinical details were available in 37. Commonest presentation was abnormal uterine bleeding. Serum CA125 was raised in 16.1% and Inhibin in 58.8%. Seventy percent were in stage I. Disease recurrence was associated with higher stage (P = 0.007). The most frequent pattern was diffuse sheets (47%). Call-Exner bodies were absent in 22.2%. Grooves with score 1, 2, and 3 were seen in 35.8%, 23.5%, and 13.6%, respectively. Anisonucleosis was present in 26.7%, necrosis in 11.1%, and lympho-plasmacytic infiltrate in 43%. Out of total, 93.3% had <10 mitosis/10 HPF and 43.2% had recurrence, most with high Ki-67 (P = 0.064). Conclusion: Our study outlines histomorphological spectrum of GCT and emphasizes its frequent occurrence in lower stages with late recurrences. The presence of grooves may indicate granulosa-cell origin. Call-Exner bodies are not a necessity. Histomorphological features are not prognostically important. However, prognostic value of Ki-67 cannot be excluded. Limitation of the study was a small number of cases with follow-up.