RESUMEN
Objective: Several medications have been used for sedation in children in dentistry and intra-nasal route has been reported to be an efficient way regarding patient cooperation. The aim of the present study was to compare the changes in physiologic parameters following intra-nasal midazolam and ketamine administration
Methods: In this randomized cross-over double-blind trial, 17 uncooperative 3-6 years old children requiring at least two dental treatments were selected randomly and received intra-nasal ketamine [0.5 mg/kg] and midazolam [0.2 mg/kg] prior to the treatment using the other drug in the next visit. Physiologic parameters including blood pressure, heart rate, respiratory rate and O[2] saturation were measured and compared during the different time intervals using two way repeated measure ANOVA
Results: The patients showed higher blood pressure and heart rate following ketamine administration compared to midazolam [p<0.001]. No significant difference was found between the drugs at different time intervals regarding respiratory rate and O[2] saturation. [p>0.05]
Conclusion: In spite of significant differences between midazolam and ketamine regarding heart rate and blood pressure, both drugs can b e used as effective sedative medications without treatment interruption in children