RESUMEN
Background: Brain ischemia is one of the leading causes of death and physical disability worldwide. Flavonoids found in Raspberry fruit [RF] play an important role against oxidative stress injuries in the biological systems
Objective: The present study was carried out to evaluate the effect of RF on ischemia/reperfusion [I/R]-induced brain injury in rats
Methods: In the present experimental study, 42 wistar adult male rats weighing 200-250 g were divided into six groups as sham operated [Sh], ischemia/reperfusion [I/R] received normal saline [I+Veh], I/R groups treated with RF extract [I+RF, 50, 100, or 200 mg/kg, IP, respectively]. The global cerebral I/R was induced by occluding bilateral common carotid arteries for 30 min, followed by reperfusion. Behavioral test performed with shuttle box and analgesia test performed with tail flick test
Results: Administration of RF extract 50, 100, or 200 mg/kg doses increased passive avoidance memory significantly [P<0.05]. In addition, RF extract delayed the emergence of painful reflux in tail flick test significantly [P<0.05]
Conclusion: Results of this study showed that RF extract possesses protective effects against pain and memory deficits induced by I/R, which may be due to its anti-inflammatory and antioxidant effects