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Journal of Central South University(Medical Sciences) ; (12): 746-750, 2008.
Artículo en Chino | WPRIM | ID: wpr-814003

RESUMEN

OBJECTIVE@#To compare protein levels of pro-inflammatory factors and bone formation mediators in the fibrous cap and shoulder region of non-calcified and calcified carotid endarterectomy (CEA) plaques.@*METHODS@#Twenty-two CEA plaques were classified as non-calcified and calcified groups (n=11 each) in accordance with the American Heart Association (AHA) consensus in 1995. To make frozen sections and H&E staining using plaque, the mean percent of carotid stenosis and calcification area was determined by quantitative histomorphometry. The protein levels of pro-inflammatory interleukin-8 (IL-8), monocyte chematactic protein-1 (MCP-1), bone formation mediators bone morphogenetic protein-6 (BMP-6), and osteocalcin in the fibrous cap and shoulder region of plaques were determined by western blot and were quantified using ImageJ software.@*RESULTS@#MCP-1 and IL-8 protein were 1.3 (P>0.05) and 1.5 (P0.05) and 2.1 (P<0.01) folds greater in the calcified plaques compared with those of the non-calcified plaques.@*CONCLUSION@#Inflammation is more likely to occur in non-calcified carotid plaques, and calcification in the plaques may be associated with bone formation, which indicates that decreased inflammation may be the beginning of calcification in carotid atherosclerotic plaques.


Asunto(s)
Humanos , Aterosclerosis , Metabolismo , Patología , Proteína Morfogenética Ósea 6 , Metabolismo , Calcinosis , Metabolismo , Patología , Estenosis Carotídea , Metabolismo , Patología , Quimiocina CCL2 , Metabolismo , Endarterectomía Carotidea , Inflamación , Metabolismo , Patología , Interleucina-8 , Metabolismo
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