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Braz. oral res ; 22(4): 322-327, 2008. graf, tab
Artículo en Inglés | LILACS | ID: lil-502186

RESUMEN

This study evaluated the frequency of the tumor necrosis factor-alpha (TNF-α) -308 G/A polymorphism in Brazilians with periodontal health (PH = 51), chronic periodontitis (CP = 74) and generalized aggressive periodontitis (GAgP = 38). Human DNA was obtained from mouthwash samples and TNF-α genotyping was performed by PCR and RFLP analyses. Differences in clinical and genetic parameters among groups were sought by Kruskal-Wallis, χ² and Fisher's exact tests. The allele -308G was detected in 91.7 percent, whereas the allele -308A was found in 35.4 percent of all subjects. No significant differences were observed in the frequency of these alleles (χ² = 2.610, p > 0.05) and the genotypes G/G, G/A, and A/A (χ² = 2.547, p = 0.636) among groups. The data suggest that the TNF-α -308 G/A polymorphism is not associated with periodontitis in this Brazilian population.


Asunto(s)
Adolescente , Femenino , Humanos , Masculino , Adulto Joven , Polimorfismo Genético , Enfermedades Periodontales/genética , Factor de Necrosis Tumoral alfa/genética , Alelos , Periodontitis Agresiva/genética , Brasil , Estudios de Casos y Controles , Periodontitis Crónica/genética , Marcadores Genéticos , Predisposición Genética a la Enfermedad , Genotipo , Salud Bucal , Reacción en Cadena de la Polimerasa , Enfermedades Periodontales/diagnóstico , Estadísticas no Paramétricas , Adulto Joven
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