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Objective To investigate the diagnostic value of serum hyaluronic acid and laminin in patients with coronary heart disease complicated with myocardial infarction.Methods 100 patients with coronary heart disease(CHD) were selected as the coronary heart disease group, and the patients with CHD and myocardial infarction(AMI) were selected as the infarct group in our hospital from July 2015 to July 2016.The levels of serum hyaluronic acid and laminin were compared between the two groups, and the levels of hyaluronic acid and laminin were analyzed.Results The expression of LN and HA in the infarction group were significantly higher than those in the coronary heart disease group(Pdouble branch lesions > single vessel disease(P<0.05).LN and HA expression in different coronary artery lesions in the infarction group were significantly higher than those in the coronary heart disease group(P<0.05).The expression of LN and HA in patients with anterior and inferior wall myocardial infarction were significantly higher than those in anterior wall and inferior wall infarction(P<0.05).Conclusion The increase of serum HA and LN in patients with coronary heart disease may cause acute myocardial infarction.
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Objective To study the the association of Hs-cTNT level with coronary flow in patients with ST-segment elevation myocardial infarction(STEMI) undergoing percutaneous coronary intervention(PCI).Methods130 cases with STEMI in hospital from January 2014 to December 2014 were divided into the positive group and the negative group according the level of Hs-cTNT.Multivariate analysis were used to examine the association of Hs-cTNT with coronary flow in patients with ST-Segment elevation myocardial infarction undergoing primary PCI.ResultsThe incidence of no reflow in the positive group was significantly higher than that in the negative group (P<0.05) The left ventricular ejection fraction in the positive group was significantly lower than that in the negative group (P<0.05).Multivariate analysis showed that Hs-cTNT was independently associated with coronary flow no-reflow in patients with acute STEMI post-PCI and TIMI flow fractionation events(P<0.05).ConclusionHypersensitivity troponin T is an effective marker for predicting coronary artery flow damage in patients with STEMI after PCI and evaluating risk stratification in patients with STEMI.
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The effects of ketotifen, cimetidine & erythromycin on thebphy-lline pharmacokinetics in rabbits were studied. The results suggested that the elimination half-life of theophylline decresed from 2.74 ? 0.75 to 2.33 ? 0.56 h & the clearance of theophylline increased from 0.15?0.036 to 0.13 ? 0.047 1/kg?h-1 by ketotifen.The elimination half-life of theophylline increased from 2 .08 ? 0.33 to 2.6l?0.45 h & the clearance decreased from 0.2l?0.03 to 0.16?0.03 1/kg?h-1 by cimetidine.The elimination half-life of theophylline increased from 2.39 ? 0.43 to 3.54?0.89 h & the clearance decreased from 0.15?0.03 to 0.12?0.03 1/kg?h-1 by erythromycin.