RESUMEN
Doxorubicin [DOX] is a potent antineoplastic antibiotic. Studies focusing on DOX-cardiotixicity have yielded numerous insights into the proatherogenic changes in lipoprotein metabolism. It is clear from recent evidences that some hypolipemic drugs improve DOX induced cardiotoxicity. On the other hand, both infection and inflammation are associated with a systemic host response characterized by many proatherogenic alterations. This study was designed to clarify the effect of multiple doses of DOX alone or during endotoxemia on lipogram pattern in male rats and elucidate the possible protective effect of supplemented taurine [Tau] or rolipram [Rol] against DOX-cardiomyopathy. To address these issues, male albino rats [180 +/- 20 g] were randomly assigned to six main experimental groups, in addition to a normal control group: DOX was given individually [2mg/kg/week, IP], or in combination with LPS [1mg/kg, IP, 18 hrs. before sampling, Tau [lg/kg/day in drinking water, 10 days before DOX and daily thereafter], Rol[3 mg/kg IP before DOX treatment and then every 2 weeks], LPS + Tau and LPS + Rol respectively. Each group was given the selected agents for 6 weeks. Blood aliquots were collected for serum and plasma separation. TG, TC, HDLC and susceptibility of non HDLC to oxidation were evaluated in plasma, whereas FFAs and albumin were estimated in serum samples. DOX induced significant increase in TG [2.9 fold], TC [2 fold], oxidized lipoproteins and FFAs [P<0.01]. Hypoalbuminemia [by 43.6 %], atherogenic index [TC/HDLc] was significantly elevated after 6 weeks [P<0.01] in comparison with controls. LPS exaggerated the hypertriglyceridemia effect of DOX, in addition to elevated levels of both oxidized lipoproteins and FFAs [P<0.00l]. Non-significant fluctuations in TC, HDLC, thermogenic index and albumin were observed in comparison with DOX groups. The use of Tau or Rol in combination with DOX or DOX LPS improved the lipid profile as manifested by reducing TG, TC, oxidized lipoproteins, atherogenic index and FFAs [P<0.001]. Serum albumin levels were significantly elevated following the use of these combination regimens [P<0.001] in comparison with both DOX or DOX-LPS groups respectively