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J Biosci ; 2008 Dec; 33(5): 723-30
Artículo en Inglés | IMSEAR | ID: sea-111047

RESUMEN

Bisabolane-type sesquiterpenes are a class of biologically active compounds that has antitumour,antifungal, antibacterial,antioxidant and antivenom properties.We investigated the effect of two new highly oxygenated bisabolane-type sesquiterpenes (HOBS)isolated from Cremanthodium discoideum (C.discoideum) on tumour cells. Our results showed that HOBS induced morphological differentiation and reduced microvilli formation on the cell surface in SMMC-7721 cells.Flow cytometry analysis demonstrated that HOBS could induce cell-cycle arrest in the G1 phase. Moreover,HOBS was able to increase tyrosine-alpha ketoglutarate transaminase activity,decrease alpha- foetoprotein level and gamma-glutamyl transferase activity. In addition,we found that HOBS inhibited the anchorage- independent growth of SMMC-7721 cells in a dose-dependent manner.Taken together,all the above observations indicate that HOBS might be able to normalize malignant SMMC-7721 cells by inhibiting cell proliferation and inducing redifferentiation.


Asunto(s)
Antineoplásicos Fitogénicos/química , Asteraceae/química , Carcinoma Hepatocelular/metabolismo , Ciclo Celular/efectos de los fármacos , Diferenciación Celular/efectos de los fármacos , Hepatocitos/efectos de los fármacos , Humanos , Estructura Molecular , Sesquiterpenos/química , Relación Estructura-Actividad , alfa-Fetoproteínas/metabolismo , gamma-Glutamiltransferasa/metabolismo
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