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1.
Korean Journal of Dental Materials ; (4): 17-28, 2023.
Artículo en Inglés | WPRIM | ID: wpr-1002144

RESUMEN

The purpose of this study is to analyze hazardous substances that can be eluted from polymer instruments used in dentistry in vitro. In the study, Dental polymer based hand instruments were eluted with exaggerated conditions (4 g/20 mL, 50 ℃, 72 h) in accordance with ISO 10993-12:2021. Appearance, pH, potassium permanganate-reducible substances, UV spectrum, residue on evaporation, and heavy metals. The additional test was performed by GC/MS for Bisphenol A. As a result, the extracts of 10 types of dental polymer based hand instruments showed colorless, transparent, and no foreign substances. pH was between 0.9 to 1.7. the difference in potassium permanganate consumption was 0.1 to 0.5 mL. The absorbance (220~350 nm) was less than 0.05, and the evaporation residue was 0.5 to 0.8 mg. Concentration of Pb was less than 4 ppm, and BPA was not detected in all extracts. It was confirmed that the 10 types of polymer materials used in this study did not exceed the regulated amount of hazardous substances set by the domestic regulatory body (Ministry of Food and Drug Safety (MFDS), Korea). These results suggest that these polymers could be safely used in the oral cavity as dental instruments.

2.
Kidney Research and Clinical Practice ; : 231-241, 2022.
Artículo en Inglés | WPRIM | ID: wpr-938418

RESUMEN

The limited literature on mental illness in end-stage kidney disease (ESKD) patients suggests that this disease is common and burdensome but underrecognized in clinical practice. This study aimed to analyze the prevalence of mental illness in ESKD patients. Methods: We assessed the prevalence and patterns of mental illnesses in a nationwide cohort of patients diagnosed with ESKD between January 1, 2008, and December 31, 2017. The risk of mental illness was evaluated using a multivariable Cox proportional hazards model. Results: A total of 70,079 patients met all study inclusion criteria. A total of 28.3% of patients had mental illness, and the specific distribution was as follows: depression, 16.8%; anxiety, 20.0%; somatoform/conversion disorder, 0.9%; stress reaction/adjustment disorder, 2.5%; and substance abuse disorder, 0.6%. The frequency of mental illness was highest in patients on hemodialysis (HD), followed by patients on peritoneal dialysis (PD) and kidney transplant (KT) patients. The peak rate of mental illness in HD and PD patients was reached 1 to 2 years after renal replacement therapy initiation, but the peak rate of most mental illnesses in KT patients occurred before surgery. The prevalence of depression was 2.19 times higher in HD patients and 1.97 times higher in PD patients than in KT patients. Conclusion: ESKD patients are at high risk of mental illness, and the prevalence of mental illness is highest in HD patients. Since the onset of mental illness occurs around the initiation of renal replacement therapy, clinicians need to pay attention to mental illness when treating ESKD patients.

3.
Clinical Pediatric Hematology-Oncology ; : 21-24, 2022.
Artículo en Inglés | WPRIM | ID: wpr-924816

RESUMEN

Acquired hemophilia A (AHA) is a rare bleeding disorder, especially in adolescents and young adults (AYAs) attributable to the development of autoantibodies against coagulation factor VIII (FVIII). AHA diagnosis is difficult; patients lack any history of coagulopathy. We report here on an AYA with AHA who responded well to treatment. A 19-year-old woman visited our hospital with painful swelling of the right lower leg. She had no past or familial history of a bleeding disorder. The initial laboratory data revealed a prolonged activated partial thromboplastin time and an uncorrected mixing test result. The FVIII activity was below 1% and the FVIII antibody level 22.4 Bethesda units. She was diagnosed with AHA and treated with recombinant activated coagulation factor VII, activated prothrombin complex concentrates and an oral steroid. After 9 months, FVIII antibody level was negative and the FVIII activity was normalized. AHA is very rare especially in AYAs, but physicians must be suspicious about the disorder and plan specialized coagulation tests to diagnose the disease. An early diagnosis of acquired bleeding disorders should be done for initiating the adequate treatment immediately by both controlling the acute bleeding episode and eliminating FVIII antibodies.

4.
Kidney Research and Clinical Practice ; : 419-431, 2021.
Artículo en Inglés | WPRIM | ID: wpr-917055

RESUMEN

Background@#Optimal estimated glomerular filtration rate (eGFR) to start maintenance dialysis is controversial. Observational studies have reported that initiation of dialysis at high eGFRs is associated with worse postdialysis survival. @*Methods@#We retrospectively investigated 1,038 incident dialysis patients who started maintenance dialysis during 2010-2015. Patients were assessed for comorbidities and adverse events during the transitional period of dialysis initiation. Patients were classified as planned dialysis (PD) vs. unplanned dialysis (UD) according to indications for dialysis initiation. @*Results@#UD group comprised 352 patients (33.9%). Mean eGFR at dialysis initiation was higher in UD patients than PD patients (7.9 ± 5.1 mL/min/1.73 m2 vs. 5.9 ± 3.4 mL/min/1.73 m2, p < 0.001). Mean Davies comorbidity index in the UD group was higher than in the PD group (1.3 ± 1.0 vs. 0.9 ± 1.0, p < 0.001). In multivariable Cox regression, patients with more comorbidities experienced more ischemic heart disease (hazard ratio [HR], 4.36; 95% confidence interval [CI], 1.71–11.14) in the medium-risk group and HR of 8.84 (95% CI, 3.06–25.55) in the high-risk group (vs. low-risk group, p < 0.001)) during the predialysis period. High-risk group had increased postdialysis mortality (HR, 2.48; 95% CI, 1.46–4.20; p = 0.001). Adjusted HR of mortality was higher in the medium-risk group of UD patients (HR, 1.72; 95% CI, 1.16–2.56; p = 0.007). @*Conclusion@#Patients with more comorbidities were at increased risk of predialysis ischemic heart disease and postdialysis mortality. UD patients in the medium-risk population had increased risk of postdialysis mortality. Dialysis start should be individualized by considering comorbidities.

5.
Diabetes & Metabolism Journal ; : 933-937, 2020.
Artículo en Inglés | WPRIM | ID: wpr-890319

RESUMEN

Knowledge of the epidemiologic characteristics of end-stage kidney disease (ESKD) patients is essential. The trends in the prevalence, incidence, and mortality rates of ESKD were analyzed retrospectively using the Korean National Health Insurance ServiceNational Sample Cohort database between 2006 and 2015. From 2006 to 2015, the incidence of ESKD decreased from 28.6 to 24.0 per 100,000 people and showed a decreasing pattern with or without diabetes mellitus. However, the incidence of those aged ≥75 years increased, as did the mean age at the onset of ESKD. From 2007 to 2015, the prevalence of ESKD increased in all age groups, but particularly in those aged ≥75 years. The prevalence of ESKD differed by sex and diabetes mellitus status and this gap widened over time. Mortality rates in ESKD patients remained relatively constant throughout the study period. However, mortality rates in ESKD without diabetes decreased over the same period.

6.
Diabetes & Metabolism Journal ; : 933-937, 2020.
Artículo en Inglés | WPRIM | ID: wpr-898023

RESUMEN

Knowledge of the epidemiologic characteristics of end-stage kidney disease (ESKD) patients is essential. The trends in the prevalence, incidence, and mortality rates of ESKD were analyzed retrospectively using the Korean National Health Insurance ServiceNational Sample Cohort database between 2006 and 2015. From 2006 to 2015, the incidence of ESKD decreased from 28.6 to 24.0 per 100,000 people and showed a decreasing pattern with or without diabetes mellitus. However, the incidence of those aged ≥75 years increased, as did the mean age at the onset of ESKD. From 2007 to 2015, the prevalence of ESKD increased in all age groups, but particularly in those aged ≥75 years. The prevalence of ESKD differed by sex and diabetes mellitus status and this gap widened over time. Mortality rates in ESKD patients remained relatively constant throughout the study period. However, mortality rates in ESKD without diabetes decreased over the same period.

7.
Korean Journal of Medicine ; : 340-343, 2020.
Artículo | WPRIM | ID: wpr-836678

RESUMEN

Multiple endocrine neoplasia type 1 (MEN 1) is an autosomal dominant disorder characterized by two or more tumors of the parathyroid gland, duodenum-pancreas, and anterior pituitary. Membranous nephropathy is the most common manifestation of paraneoplastic glomerulopathy. However, minimal change disease in patients with MEN 1 has yet to be reported. Here, we report a case of minimal change disease in a 59-year-old man with MEN 1, along with a review of the relevant literature.

8.
Journal of Liver Cancer ; : 143-148, 2019.
Artículo en Inglés | WPRIM | ID: wpr-765715

RESUMEN

Hepatic solitary fibrous tumors (SFTs) are mostly benign and rare because of information regarding the clinical symptoms, treatment, and prognosis of their malignant forms is currently lacking. A literature review concerning malignant SFTs revealed that there were a few cases where patients experienced abdominal right upper quadrant (RUQ) pain as their first clinical symptom, and metastases were found after being diagnosed with hepatic SFT. Here, we report a patient who was previously healthy without any clinical symptoms such as RUQ pain or weight loss, but had the appearance of a metastatic mass as the first clinical presentation before a primary hepatic SFT was detected.


Asunto(s)
Humanos , Neoplasias Hepáticas , Metástasis de la Neoplasia , Pronóstico , Sarcoma , Tumores Fibrosos Solitarios , Pérdida de Peso
9.
Kidney Research and Clinical Practice ; : 69-76, 2018.
Artículo en Inglés | WPRIM | ID: wpr-713366

RESUMEN

BACKGROUND: For phosphate control, patient education is essential due to the limited clearance of phosphate by dialysis. However, well-designed randomized controlled trials about dietary and phosphate binder education have been scarce. METHODS: We enrolled maintenance hemodialysis patients and randomized them into an education group (n = 48) or a control group (n = 22). We assessed the patients’ drug compliance and their knowledge about the phosphate binder using a questionnaire. RESULTS: The primary goal was to increase the number of patients who reached a calcium-phosphorus product of lower than 55. In the education group, 36 (75.0%) patients achieved the primary goal, as compared with 16 (72.7%) in the control group (P = 0.430). The education increased the proportion of patients who properly took the phosphate binder (22.9% vs. 3.5%, P = 0.087), but not to statistical significance. Education did not affect the amount of dietary phosphate intake per body weight (education vs. control: −1.18 ± 3.54 vs. −0.88 ± 2.04 mg/kg, P = 0.851). However, the dietary phosphate-to-protein ratio tended to be lower in the education group (−0.64 ± 2.04 vs. 0.65 ± 3.55, P = 0.193). The education on phosphate restriction affected neither the Patient-Generated Subjective Global Assessment score (0.17 ± 4.58 vs. −0.86 ± 3.86, P = 0.363) nor the level of dietary protein intake (−0.03 ± 0.33 vs. −0.09 ± 0.18, P = 0.569). CONCLUSION: Education did not affect the calcium-phosphate product. Education on the proper timing of phosphate binder intake and the dietary phosphate-to-protein ratio showed marginal efficacy.


Asunto(s)
Humanos , Peso Corporal , Adaptabilidad , Diálisis , Dieta , Proteínas en la Dieta , Educación , Hiperfosfatemia , Educación del Paciente como Asunto , Fosfatos , Diálisis Renal
10.
Korean Journal of Clinical Pharmacy ; : 138-145, 2018.
Artículo en Coreano | WPRIM | ID: wpr-715023

RESUMEN

BACKGROUND: Presently, a multidisciplinary team of doctors, pharmacists, nurses, and dietitians provides patient education to impart information on chemotherapy. However, studies on multidisciplinary education satisfaction are inadequate. In this study, we aimed to contribute to the improvement of quality of multidisciplinary education counseling for patients with cancer by developing a satisfaction questionnaire and analyzing the satisfaction survey. METHODS: A questionnaire was developed by an expert group, and the responses were recorded using the 5-point Likert scale. After conducting a pre-test, factor analysis was performed to evaluate validity. The reliability of the questionnaire was measured by Cronbach's alpha coefficient. A satisfaction survey was conducted by self-administration method. RESULTS: Based on the results of factor analysis, factors can be divided into two parts: “overall education” and “each team member's education” (total 14 questions). The construct validity and reliability of the questionnaire are sufficiently high. Fifty-one patients took the survey between January 2, 2018 and January 20, 2018. Twenty-six (51%) patients responded that they were “very satisfied” and 22 (43.1%) patients responded that they were “satisfied”. CONCLUSION: By developing a questionnaire on multidisciplinary education counseling for patients with cancer, it is possible to perform evaluation and research of cancer patient education. This study will contribute to the management and improvement of quality of multidisciplinary education.


Asunto(s)
Humanos , Consejo , Quimioterapia , Educación , Comunicación Interdisciplinaria , Métodos , Nutricionistas , Educación del Paciente como Asunto , Farmacéuticos , Reproducibilidad de los Resultados
11.
Journal of Korean Academy of Nursing ; : 610-617, 2016.
Artículo en Coreano | WPRIM | ID: wpr-164043

RESUMEN

PURPOSE: Smoking cessation is strongly recommended for every smoker after ischemic stroke, but many patients fail to quit smoking. An improved smoking cessation rate has been reported with intensive behavioral therapy during hospitalization and supportive contact after discharge. The aim of this study was to demonstrate the usefulness of the timely interventions for smoking cessation in men with acute ischemic stroke. METHODS: Patients who participated in the timely interventions strategy (TI group) were compared with those who received conventional counseling (CC group). In the TI group, a certified nurse provided comprehensive education during admission and additional counseling after discharge. Outcome was measured by point smoking success rate and sustained smoking cessation rate for 12 months. RESULTS: Participants, 157 men (86 of the TI group and 71 of the CC group), were enrolled. Mean age was 58.25 ± 11.23 years and mean initial National Institutes of Health Stroke Scale score was 4.68 ± 5.46. The TI group showed a higher point smoking success rate compared with the CC group (p= .003). Multiple logistic regression analysis showed that the TI group was 2.96-fold (95% CI, 1.43~6.13) more likely to sustain smoking cessation for 12 months than the CC group. CONCLUSION: Findings indicate that multiple interventions initiated during hospital stay and regular follow-up after discharge are more effective than conventional smoking cessation counseling in men with acute ischemic stroke.


Asunto(s)
Humanos , Masculino , Control de la Conducta , Infarto Cerebral , Consejo , Educación , Estudios de Seguimiento , Hospitalización , Tiempo de Internación , Modelos Logísticos , Humo , Cese del Hábito de Fumar , Fumar , Accidente Cerebrovascular
12.
Kidney Research and Clinical Practice ; : 207-211, 2015.
Artículo en Inglés | WPRIM | ID: wpr-79191

RESUMEN

BACKGROUND: Estimated glomerular filtration rate (eGFR) is one of the most important guidelines in deciding the optimal timing of dialysis initiation. In the present study, we calculated the eGFR at the time of hemodialysis (HD) initiation using 5 commonly used equations to relate them with clinical and laboratory characteristics of the patients and to evaluate which of these equations best define the eGFR at HD initiation. METHODS: We retrospectively analyzed 409 end-stage renal disease patients who were newly started on HD treatment in our institution. The eGFR was calculated using the Cockcroft-Gault equation, the Cockcroft-Gault equation corrected for body surface area, the Modification of Diet in Renal Disease (MDRD) equation, the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation, and the Nankivell equation. RESULTS: The mean eGFRs at HD start were significantly different across the equations. The mean eGFR was 7.8 mL/min for the corrected Cockcroft-Gault equation, 7.7 mL/min for the Cockcroft-Gault equation, 6.2 mL/min/1.73 m2 for the MDRD equation, and 5.6 mL/min/1.73 m2 for the CKD-EPI equation. The corrected Cockcroft-Gault, the MDRD, and the CKD-EPI equations were well correlated with all CKD-specific complications including hypertension, anemia, hyperkalemia, metabolic acidosis, hypocalcemia, hyperphosphatemia, and hyperparathyroidism. The mean eGFR calculated by the corrected Cockcroft-Gault equation showed the lowest coefficient of variation among all the equations. CONCLUSIONS: The eGFR at HD initiation are significantly different according to the used eGFR equations, and the corrected Cockcroft-Gault equation may be the best in defining the eGFR at HD initiation.


Asunto(s)
Humanos , Acidosis , Anemia , Superficie Corporal , Conducta Cooperativa , Diálisis , Dieta , Epidemiología , Tasa de Filtración Glomerular , Hiperpotasemia , Hiperparatiroidismo , Hiperfosfatemia , Hipertensión , Hipocalcemia , Fallo Renal Crónico , Diálisis Renal , Insuficiencia Renal Crónica , Estudios Retrospectivos
13.
Kidney Research and Clinical Practice ; : 233-236, 2015.
Artículo en Inglés | WPRIM | ID: wpr-79187

RESUMEN

Mushroom-related poisoning can cause acute kidney injury. Here we report a case of acute kidney injury after ingestion of Amanita punctata, which is considered an edible mushroom. Gastrointestinal symptoms occurred within 24 hours from the mushroom intake and were followed by an asymptomatic period, acute kidney injury, and elevation of liver and pancreatic enzymes. Kidney function recovered with supportive care. Nephrotoxic mushroom poisoning should be considered as a cause of acute kidney injury.


Asunto(s)
Lesión Renal Aguda , Agaricales , Amanita , Ingestión de Alimentos , Riñón , Hígado , Intoxicación por Setas , Intoxicación
14.
The Korean Journal of Critical Care Medicine ; : 328-330, 2014.
Artículo en Inglés | WPRIM | ID: wpr-770832

RESUMEN

Urine discoloration occurs in the intensive care unit (ICU) due to many causes such as medications, metabolic disorders, and infections. Propofol is advocated as one of the first line sedatives in the ICU, but it is not well known to the intensivists that propofol can induce urine color change. We experienced two cases of green urine after propofol infusion. Propofol should be warranted as the cause of urine discoloration during ICU stay.


Asunto(s)
Hipnóticos y Sedantes , Unidades de Cuidados Intensivos , Propofol
15.
Korean Journal of Anesthesiology ; : S115-S117, 2014.
Artículo en Inglés | WPRIM | ID: wpr-185517

RESUMEN

No abstract available.


Asunto(s)
Adulto , Humanos , Linfohistiocitosis Hemofagocítica
16.
Endocrinology and Metabolism ; : 48-53, 2014.
Artículo en Inglés | WPRIM | ID: wpr-121041

RESUMEN

BACKGROUND: Hypopituitarism is associated with osteoporosis and osteopenia especially when hypogonadotropic hypogonadism is present. Despite hypopituitarism being an important cause of secondary osteoporosis, osteoporosis in patients receiving surgery for pituitary tumors in Korea has not been studied. In this study, we evaluated the effects of testosterone replacement therapy (TRT) on bone mineral density (BMD) in postoperative hypogonadal patients with pituitary tumors. METHODS: To examine the effect of TRT on BMD, we performed a retrospective observational study in 21 postoperative male patients who underwent pituitary tumor surgery between 2003 and 2012 at the Ajou University Hospital. Testosterone was replaced in postoperative hypogonadal patients by regular intramuscular injection, daily oral medication, or application of transdermal gel. BMD (g/cm2) measurements of central skeletal sites (lumbar spine, femoral neck, and total femur) were obtained using dual-energy X-ray absorptiometry (GE Lunar). For lumbar spine BMD, L1 to L4 values were chosen for analysis. Femur neck and total femur were also analyzed. RESULTS: During the follow-up period (mean, 56 months; range, 12 to 99 months) serum testosterone levels increased with the administration of TRT (P=0.007). There was significant improvement (4.56%+/-9.81%) in the lumbar spine BMD compared to baseline BMD. There were no significant changes in the femur neck BMD or total femur BMD. We did not find any statistically significant relationships between changes in testosterone levels and BMD using Spearman correlation analysis. CONCLUSION: Our results indicated that TRT used in the postoperative period for hypogonadal pituitary tumor surgery patients may have beneficial effects on the BMD of the spine.


Asunto(s)
Humanos , Masculino , Absorciometría de Fotón , Densidad Ósea , Enfermedades Óseas Metabólicas , Fémur , Cuello Femoral , Estudios de Seguimiento , Hipogonadismo , Hipopituitarismo , Inyecciones Intramusculares , Corea (Geográfico) , Estudio Observacional , Osteoporosis , Neoplasias Hipofisarias , Periodo Posoperatorio , Estudios Retrospectivos , Columna Vertebral , Testosterona
17.
Cancer Research and Treatment ; : 312-316, 2014.
Artículo en Inglés | WPRIM | ID: wpr-199239

RESUMEN

Subcutaneous panniculitis-like T cell lymphoma (SPTL) is a distinctive cutaneous lymphoma characterized by an infiltration of subcutaneous tissue by neoplastic T cells, similar to panniculitis. It is well-established that patients who are diagnosed with SPTL usually respond poorly to chemotherapy, showing fatal outcome. As a first line treatment for SPTL, anthracycline-based chemotherapy was most frequently used. For the treatment of SPTL, the efficacy of cyclosporine A has been recently reported in relapsed SPTL after anthracycline-based chemotherapy. However, it is still not clear whether cyclosporine A can be used as a first-line treatment against SPTL. Here, we report a case of SPTL, which achieved complete remission for nine years after first-line cyclosporine A therapy. This study suggests that cyclosporine A can induce a complete long-term remission as a first-line treatment.


Asunto(s)
Humanos , Ciclosporina , Quimioterapia , Resultado Fatal , Linfoma , Linfoma de Células T , Paniculitis , Tejido Subcutáneo , Linfocitos T
18.
Korean Journal of Critical Care Medicine ; : 328-330, 2014.
Artículo en Inglés | WPRIM | ID: wpr-145398

RESUMEN

Urine discoloration occurs in the intensive care unit (ICU) due to many causes such as medications, metabolic disorders, and infections. Propofol is advocated as one of the first line sedatives in the ICU, but it is not well known to the intensivists that propofol can induce urine color change. We experienced two cases of green urine after propofol infusion. Propofol should be warranted as the cause of urine discoloration during ICU stay.


Asunto(s)
Hipnóticos y Sedantes , Unidades de Cuidados Intensivos , Propofol
19.
Journal of Bone Metabolism ; : 51-55, 2013.
Artículo en Inglés | WPRIM | ID: wpr-14728

RESUMEN

Vitamin D is an important hormone that can be a role of bone and calcium metabolism in the human organ. Thus, vitamin D deficiency could contribute to the severity of metabolic bone disease. The osteomalacia, one of the metabolic bone diseases, is the softening of the bones caused by defective bone mineralization secondary to inadequate amounts of available phosphorus and calcium. We experienced a case of osteomalacia presented with walking disturbance, 30 year-old young aged man, caused by vitamin D deficiency due to strict vegetarian diet and lack of sunlight exposures.


Asunto(s)
Anciano , Humanos , Masculino , Adulto Joven , Enfermedades Óseas Metabólicas , Calcificación Fisiológica , Calcio , Dieta Vegetariana , Osteomalacia , Fósforo , Luz Solar , Vitamina D , Deficiencia de Vitamina D , Caminata
20.
Journal of Bone Metabolism ; : 57-60, 2013.
Artículo en Inglés | WPRIM | ID: wpr-14727

RESUMEN

CATCH 22 Syndrome is caused by chromosome 22q11.2 microdeletion, characterized by developmental abnormalities of the third and fourth pharyngeal pouches. It has a prevalence estimated at 1:3,000-1:9,000. Most deletions occurs sporadic, but autosomal dominant inheritance observed in 6-10% of cases. CATCH22 often diagnosed due to hypocalcemia during neonatal period or decreased immunity or facial defect, so it is very rare being diagnosed CATCH22 in adulthood. We report a 57 year old female who referred to mental change due to hypocalcemia and is diagnosed CATCH22. She was presented with hypoparathyroidism, single kidney due to renal agenesis, and mild facial defect. Our patient responded well to calcium and vitamin D treatment and she is on follow-up in outpatient clinic.


Asunto(s)
Femenino , Humanos , Instituciones de Atención Ambulatoria , Calcio , Anomalías Congénitas , Síndrome de DiGeorge , Estudios de Seguimiento , Hipocalcemia , Hipoparatiroidismo , Riñón , Enfermedades Renales , Prevalencia , Vitamina D , Testamentos
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