RESUMEN
Objective] To evaluate the immune effect of hepatitis B vaccine by different inocula-ting programs for adults as 0-1-3 month, 0-1-6 month and 0-1-12 month and to provide evidence for the development of adult immunization strategy. [ Methods] In Tongxiang City of Zhejiang Province, 10μg of hepatitis B vaccine was voluntarily inoculated by different immunization programs as 0 -1 -3 month, 0-1-6 month or 0 -1 -12 month among adults aged 16 to 49 years.Quantitative detection of anti-HBs was conducted after 1 month and 1 year of immunization, and the positive seroconversion rates and geometric mean titers of anti-HBs ( GMT) were evaluated. [ Results] Totally 682 subjects were evaluated.The anti-HBs positive rates were 99.85% after 1 month of immunization, and 70.23% after 1 year of immunization.It was observed that GMT of anti-HBs was higher with adults of younger age. [ Conclusion] Adults can achieve better immune effect by inoculation of 10μg of hepatitis B vaccine and when it is done in target population according to 0-1-6 month program,compliance is better and immune effect proves more persistent.It is suggested that hepatitis B vaccine should be inoculated for the adults as early as possible to ensure the effect and persistence of the vaccine.
RESUMEN
Objective To evaluate the immune effect of hepatitis B vaccine by different immunization schedules among adults,and to provide evidence for developing immunization strategy.Methods Adults aged 1 6 to 49 years with negative HBsAg and anti -HBs in Tongxiang city voluntarily received domestic or imported hepatitis B vaccine.These subjects were divided into 4 groups (Group A:1 0 μg domestic vaccine,0 -1 -3 schedule;group B:1 0 μg domestic vaccine,0 -1 -6 schedule;group C:1 0 μg imported vaccine,0 -1 -3 schedule;group D:1 0 μg imported vaccine,0 -1 -6 schedule). Quantitative detection of anti -HBs was conducted in 1 month and 1 year,and the anti -HBs positive rate and geometric mean titers of anti -HBs (GMT)were evaluated.Results A total of 848 subjects were evaluated.The anti -HBs positive rate was 99.76% after immunization in 1 month,and no significant differences were observed among different groups (P >0.05).The GMT of anti -HBs in group A was significantly lower than that of group C and B (P <0.05),while no significant differences were observed among group B and D.The GMT of anti -HBs was significantly decreased with ages. The anti -HBs positive rate was 70.28% after immunization in 1 year,which was significantly lower than that in 1 month after immunization.Conclusion Better immune effect could be achieved by 1 0 μg domestic hepatitis B vaccine with 0 -1-3 schedule.