Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 2 de 2
Filtrar
Añadir filtros








Intervalo de año
1.
China Journal of Chinese Materia Medica ; (24): 2772-2775, 2008.
Artículo en Chino | WPRIM | ID: wpr-324809

RESUMEN

<p><b>OBJECTIVE</b>To investigate the tissue distribution of the diallyl disulfide (DADS) and diallyl trisulfide (DATS) in solid lipid nanoparticles loaded garlic oil (GO-SLN) in rats.</p><p><b>METHOD</b>The gas chromatography-electron capture detection (GC-ECD) method was established to determined the DADS and DATS simultaneously in the biological samples of rats after administration of 0.5 mL garlic oil injection or GO-SLN (containing about 10 mg garlic oil) via jugular vein cannula. The conditions for gas chromatographic separation were as follows. The oven temperature was set at 110 degrees C and maintained for 15 min. Temperatures at the injection port and detector were 180 degrees C and 300 degrees C, respectively. Ultra-pure nitrogen (purity > 99.999%, Shenyang Kerui Special Gases Co. Ltd., China) was used as a carrier gas and made-up gas at flow-rates of 1 mL x min(-1) and 60 mL x min(-1), respectively. All injections were carried out in the split injection mode with a split ratio of 1:10.</p><p><b>RESULT</b>The GC-ECD method was fit for determing the concentration of DADS and DATS in garlic oil. The distribution character of GO-SLN in rats had changed to some extent and the concentration of GO-SLN in tissues was higher than that of GO-Injection.</p><p><b>CONCLUSION</b>The SLN can elevate the passive targeting of drugs and lengthen their action time in tissues.</p>


Asunto(s)
Animales , Femenino , Masculino , Ratas , Compuestos Alílicos , Farmacocinética , Disulfuros , Farmacocinética , Ajo , Química , Nanopartículas , Química , Aceites de Plantas , Química , Farmacocinética , Ratas Wistar , Sulfuros , Farmacocinética
2.
China Journal of Chinese Materia Medica ; (24): 835-837, 2002.
Artículo en Chino | WPRIM | ID: wpr-271797

RESUMEN

<p><b>OBJECTIVE</b>To study the preparation of Venenum Bufonis beta-cyclodextrin inclusion complexes.</p><p><b>METHOD</b>An optimal condition was established by the uniform design. Under the optimal conditions the Venenum Bufonis beta-cyclodextrin inclusion complexes were prepared with 5 different methods.</p><p><b>RESULT</b>The ball grinding method was superior to other four methods. The bufadienolide inclusion rate of Venenum Bufonis beta-cyclodextrin prepared with ball grinding method was 85.42%.</p><p><b>CONCLUSION</b>Ball grinding method is the best method for the preparation of Venenum Bufonis beta-cyclodextrin inclusion complexes.</p>


Asunto(s)
Animales , Venenos de Anfibios , Química , Bufanólidos , Bufo bufo , Colenos , Ciclodextrinas , Portadores de Fármacos , Estabilidad de Medicamentos , Materia Medica , Química , Solubilidad , Tecnología Farmacéutica , Métodos , beta-Ciclodextrinas
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA