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0.05 ), However, all pasameters showed significantly milder or lower in interferon ? treated group than incontrol group at the 6th, 12th week( P
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Objective In order to determine the effect of colchicine(Col) on the changes of serum activity of tumour necrosis factor (TNF) induced by lipopolysaccharide(LPS) in rabbits.Methods Twelve New Zealand white rabbits were equally divided into 2 groups, namely group A and group B. Rabbits in group A were intravenously administered with 0.2ml/ kg of normal saline (NS) from 67h before LPS inje ction, while those in group B were given 0.5mg/ kg of Col instead of NS at the same time course.Endotoxic shock was induced by intravevous injection of 2?g/ kg of LPS after the challenge by Bacillus Calmette Gu?rin(BCG). Results Prior infusion of Col significantly decreased the peak levels of serum TNF activity ( P
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Toxic hepatic necrosis (THN) was induced in BALB/C mice by CCl4 infection (i.p.) and then colchicine (orally), testosterone propionate or estradiol valerate (s.c.) were administered. The experimental results reveal that the effect of colchicine on THN was better in male mice than that in femalemice.Testosterone propionate had no effect on the survival rate of male and female mice with THN, but enhanced the therapeutic effect of colchicine on THN in female mice. All male mice with estradiol died and half of them with estradiol and colchicine survived(P