Function and morphometric evaluation of intrauterine undernutrition on kidney development of the progeny

Renal function and renal morphometry of the progeny of rats submitted to 50% dietary restriction (pairfed with control group) throughout pregnancy (Rtgroup), during the first half of pregnancy (R1 group) or during the second half of pregnancy (R2 group) were studied 3 months after birth. Glomerular filtration rate (GFR) and renal plasma flow (RPF) decrease significantly in all groups when compared to control (C) (GFR, 4.44 ñ 0.12, 4.04 ñ 0.18, and 4.00 ñ 0.16 vs 6.87 ñ 0.17, and RPF, 19.06 ñ0.57, 17.00 ñ 1.14, and 13.31 ñ0.50 vs 22.57 ñ 0.67, respectively). Urinary osmolality tended to be lower in the R2 and Rt groups (887.1 ñ 42.36 and 868.0 ñ 42.36 vs 975.1 ñ 38.31 in C), and the net acid excretion calculated per ml of GFR was either maintained or stimulated (R1 group). A significant decline in the number of glomeruli occurred in R1, R2 and Rt rats (79.84 ñ 2.08, 62.30 ñ 2.07, and 58.16 ñ 2.32 vs 99.77 ñ 2.28 in C repectively). The results show that intrauterine undernutrition actually caused a deleterious effect on the number of functional nephrons

Structural and ultrastructural alterations of epithelial cells of vas deferens caused by contrast medium

In a attempt to verify experimentally any possible alterations of epithelial cells of vas deferens caused by radiopaque substance, the right and left vasa deferential of 3 rats were injected respectively with saline solution (0.9 per cent NaCl) and Conray-400 (66.8 per cent sodium iodomethamate). 72 hours later, the animals were killed by cranial trauma and histolofical sections and electronmiucrographs of their vasa deferentia were observed. The histological sections of epithelial cells of left vasa deferentia showed a decrease in height and slight changes in stereocilia as compared with those of right contralateral vasa deferentia. Electronmicrographs displayed a reduction in number and size of stereocilia and alterations of many mitochondria in epithelial cells of left vasa deferentia

Contribuicao ao estudo das variacoes anatomicas dos giros do lobulo parietal inferior no homen. / Anatomical variations of the gyri of the inferior parietal lobule in the man

Dispondo-se de 100 cerebros de individuos adultos brasileiros estudou-se a anatomia macroscopica das variacoes dos giros supramarginal e angular, os quais compoem o lobulo parietal inferior, em funcao dos 3 fatores de variacoes: sexo, grupo etnico e simetria no lado. Justifica-se a proposicao desta investigacao em face da previcao de delimitacao das areas corticais para estudos citoarquitetonicos, pela importancia da regiao enfocada na fisiologia da linguagem humana e animal, em decorrencia da complexidade que os giros e sulcos possam apresentar, pela utilidade na orientacao, localizacao e em estudos topograficos desta area e de sua extensao