RESUMEN
This study was undertaken to assess-the effects of sevoflurane anaesthesia in adult patients undergoing Craniotomy as regarding intracranial Pressure [ICP], haemodynamics, Cerebral perfiisiom pressure [CPP] Brain swelling score [BSS] end tidal carbon dioxid, arterial oxygen saturation [PaO2] and emerganc critaria, In comparison with Isoflurane. 40 adult patients [16-78] year of age, ASA II or III scheduled for elective cranitomy 20 patient [group I] receive isoflurane and 20 patient [group II] receive sevoflurane as inhalational agent with fixed technique, [Induction, Maintianee, Brain protection, Recovery, Post operative] in both group.: and evolution the difference on the variable was done. Show no significant Intra group difference as regard HR, .MABP, ICP, BSS, end tidal carbon dioxid and PaO2 [P value>0.05]. In emergance from anaesthesia were generally rapid in both but the time to extubation was rapid in sevoflurane compared to isoflurane group and the time to commands was faster in sevofiurane group, time to orientation is more rapid in sevoflurane and the time-to reach modified-Alderete score was short in sevoflurane compared to Isoflurane group. Sevoflurane provide stable hemodynamic state with no significant effect on ICP. The Postanaesthetic recovery time was short in sevoflurane group than in Isoflurane group, this make the sevoflurane an attractive choice for a rapid emergenc