RESUMEN
Background: Cardiovascular events and accelerated atherosclerosis in patients with active systemic lupus erythematosus results in significant increased morbidity and mortality. The non-traditional risk factors induce alteration in lipoprotein metabolism and the constant inflammatory and immune activity can lead to accelerated atherosclerosis
Aim: To assess prevalence of dyslipidemia in systemic lupus erythematosus patients and to study the relation of dyslipidemia to disease activity. Patients and methods: The presented study included 60 SLE adult patients [56 females and 4 males] and they were classified according to disease activity into two groups: Active Lupus: Included 30 lupus patients. Inactive Lupus: Included 30 lupus patients. 20 healthy subjects with matched age, sex and BMI were included as healthy controls
Methods: Patients underwent clinical assessment. Total cholesterol, [LDL, HDL] and triglyceride were measured
Results: Cholesterol, LDL, and TG levels were elevated in the active group compared to that in the inactive group and healthy controls. This elevation was significant [P< 0.001]. But HDL level decreased in the active group compared to the inactive and healthy controls groups. The decrease of HDL was the active group is significant [P< 0.001]
Conclusion: The elevated levels of Total cholesterol, LDL, and TG and decreased level of HDL in SLE patients are considered an independent risk factor for cardiovascular disease. The dyslipidemia and inflammatory process predispose to premature atherosclerosis and disease activity contribute to dyslipidemia and hence cardiovascular risk associated with SLE
RESUMEN
Background: The prevalence of NAFLD [non- alcoholic fatty liver disease] is increasing as it exceed [31.79%] in Middle East and the metabolic syndrome prevalence in patients with NAFLD ranges from 18% to 67%, according to the body weight. Imaging or histology is very important tools in diagnosis of NAFLD. Early detection of NAFLD is very important especially if there is a non-invasive method. The clinicians in the primary, secondary and tertiary care are in need for specific and sensitive diagnostic tool that can be used easily
Aim: To study and analyze serum lipid changes in non-alcoholic fatty liver disease of different grades
Patients and methods: 100 patients diagnosed by ultrasonography as NAFLD, whose age was more than 18 years, were included in the study. History taking, full clinical examination and anthropometric measurement of weight, height and body mass index [BMI] were done for all patients. Serum lipid profiles including total cholesterol, HDL, LDL, triglycerides, ALT, AST. CBC, fasting and 2hpp blood glucose and TSH were measured
Results: The largest group of patients [38%] was in the fifth decade of life. followed by 30% in the sixth decade of life. As the grade of NAFLD increased, there was associated significant increase in levels of serum total cholesterol [P-value 0.005], TG [P-value 0.002] LDL [P-value 0.001] and VLDL [P-value 0.003] and associated significant decrease in HDL [P-value 0.001]
Conclusions: abdominal ultrasonography and increased lipid profile values can be used to detect NAFLD early