RESUMEN
In a r and omized, placebo-controlled study the efficacy of a single intravenous [IV] bolus of tropisetron 5mg [Group T], granisetron 3mg [Group G]. tropisetron 5mg plus dexamethasone 8mg [Group T+D], granisetron 3mg plus dexamethasone 8mg [Group G+D], or saline [Group C] given at induction were compared in a group of 150 patients, [30, each group] undergoing middle ear surgery [MES]. The groups were similar with respect to demographic data and potential confounding variables. With regard to the incidence and score of postoperative nausea and vomiting [PONV] group [G+D] and group [T+D] were significantly superior to group T and G, [P<0.05]. Also tropisetron alone and in combination was significantly superior to granisetron, either alone or in combination [P<0.05]. It was reported that tropisetron was significantly superior to granisetron through 3 to 24 h than through 0 to 3 h. No statistical difference was reported between the four study groups with regard to rescue antiemetics or adverse events. In 5-hydroxy tryptamine type 3 [5-HT3] receptor antagonist tropisetron [5 mg] given as a single intravenous bolus at induction of anesthesia was excellent in preventing PONV and that combination of 5-HT3 antiemetic plus dexamethasone was more effective than each antiemetic alone for the prevention and treatment of PONV