Histopathological evidences for the antifibrogenic effect of colchicine in schistosomiasis mansoni in mice

Colchicine treated mice showed significant decrease in prevalence of fibrocellular and fibrous granulomas in liver specimens compared with corresponding control groups. Percentage of spindle cell component and red fibrillar [RF] material showed significant reduction, compared with control groups. These evidences of the antifibrogenic effect of colchicine were more prominent when treatment was given early after infection. Combined therapy with colchicine and praziquantel gave the same results. Mice treated with praziquantel alone showed no significant change compared with control groups. Colchicine showed also an immunomodulant effect evidenced by a significant decrease in the intensity of small- and medium-sized to large cell components compared with control groups

Rapid diagnosis of non-prolonged febrile illnesses necessitating fever hospital admission

Two hundred and seventy patients were studied during a 2 years period in Abbassia and Embaba fever hospitals. The duration of illness before admission was less than 20 days. Suggestive clinical symptoms and/or signs of each disease were stressed. Rapid laboratory investigations include slide typhoid agglutination test [98%] in enteric fevers, slide malta agglutination test [86%] in brucellosis, urine culture [100%] in urinary tract infection, gram stain of C.S.F. in bacterial meningitis [80%], encephalitis [0%] and meningeal irritation [0%], high vaginal swab culture [100%] in puerperal fevers, echocardiogram [100%] in infective endocarditis, high E.S.R. [100%] and positive C.R.P [71%] and/or high A.S.O [86%] in rheumatic fever, counterimmunoelectrophoresis [86%] in amoebic liver abscess, chest X-ray in pneumonia [100%], pulmonary tuberculosis [100%] and pleural effusion [100%], ultrasound of lymph nodes [100%] in tuberculous. lymphadenitis. Erysipelas and tetanus were diagnosed on clinical grounds only

case of cervical lymphadenopathy due to pediculosis

This paper reports a case of cervical lymphadenopathy due to infestation with Pediculus h. capitis. Clinically and histopathologically the case was diagnosed to a non malignant and a non specific one

Chronic salmonellosis in cases of chronic cholecystitis subjected to cholecystectomy

In this study, we tried to evaluate the presence of salmonella faecal carriers in fifty cases of chronic cholecystitis subjected to cholecystectomy. All our patients had history suggestive of typhoid fever sometime before operation. Repeated stool cultures as well as bile and gall-bladder tissue cultures gave negative results for salmonella isolation. This may be due to the fact that faecal carrier state in Egypt is much less common than the chronic urinary carriers of salmonella due to the great incidence of urinary schistosomiasis. Another factor is that chronic cholecystitis is more common than chronic salmonella faecal carriers

Changes in the intraocular pressure in chronic liver diseases with ascites

The aim of the present work is to study changes in the intraocular pressure in cases having chronic liver diseases with ascites. Fifty patients suffering from chronic liver diseases with ascites and 12 non ascitic patients as a control were studied. Careful history, thorough clinical examination, laboratory, ultrasono-graphic and endoscopic investigations were performed for every patient and contro1. The intrao-cular pressure was measured by Schiotz indentation tonometer and confirmed by hand held applanation tonometer in 3 different sittings. There was no significant difference in the mean intraocular pressure between ascitic patients and non-ascitic controls. There was positive statistical correlation between the degree of portal hypertension as manifested by congestive splenomegaly and the intraocular pressure in 38patients. The lowest intraocular pressure measurements were found in 14 patients with blood urea ranging from 68 - 152 mg. This may be explained by the osmotic effect of urea on aqueous outflow present in patients with chronic liver diseases and ascites who are prone to develop functional renal failure. There was a significant decrease in the intraocular pressure in ascitic patients after diuretic therapy when compared to values before therapy

Evaluation of the DOT enzyme-linked immunosorbent assay in diagnosis of leishmaniasis

Human sera were collected from twenty patients of parasitologically proven cutaneous leishmaniasis, 35 cases of schistosomiasis mansoni and ten normal control sera. The antileishmanial antibodies were detected by the dot enzyme-linked immunosorbent assay [dot ELISA]. The results showed that the dot ELISA had high sensitivity. However, there was a marked deal of cross reactivity with the antisera of schistosomiasis mansoni infected patients, particularly those with splenomegaly and ascites