Synthesis of certain 4 [3H] quinazolinone compounds containing imidazolinone and azomethine moieties

The synthesis of several 3-[4-arylindine-2-alkyl [aryl] 5[4H] imidazolon-1-yl] phenyl]-2-methyl-7-nitro-4 [3H]-quinazolinones are described. Structured establishment of the new compounds is substantiated by element analysis, IR and h- NMR spectra. Preliminary biological screening of some selected members showed no detectable antimicrobial activity in vitro, chloramphenicol and nystatin were included in the study for sake of comparison

Synthesis of certain 4 [3H] quinazolinones likely to possess CNN depressants and antimalarial activities

Several new 3-substituted 7-nitro-4 [3H] quinazolinones were prepared. The structures of the obtained compounds based on elemental analysis, IR and H-NMR spectra. Anti-convulsant and hypnotic activities of some compounds were tested and compared to phenytoin and pentobarbital sodium

New 4-quinazolinones as antibacterial agents

The synthesis of several new 3-[4-[arylidenehydrazino- carbonylmethyloxy] phenyl]-2-methyl-7-nitro-4 [4 93H0-quinazolinones is described. Cyclization of these hydrazones under different reaction conditions afforded the expected 5-substituted thio-oxadiazole as well as 4-acetyl-5-substituted oxadiazoline derivatives. The antibacterial activity of some of the obtained compounds is evaluated. The constitution of the new products is proved in the light of their microanalyses and nmr spectral data

Synthesis and biological activity of some novel triazolothiadzines

Some novel s-triazolo [3, 4b] 1,3,4-thiadiazines [II] and [IV] were synthesized via the reaction between 3-substitued 4-amino-5-mercapto s-triazoles [I] and the appropriate phenacyl bromides or ethyl chloroacetate, respectively. Identification of the new compounds was substantiated by element analysis, IR and NMR spectral data. Compounds IIa-k were tested for their antimicrobial activity and IVa-d for their anti-inflammatory activity

Synthesis of some new selenaand thiadiazoles containing quinazol-4-one

P-aminoacetophenone was treated with 2-methyl-3, 1-[4H]-benzoxazin-4- one [I] to produce the corresponding 2-methyl-3-[p-acetylphenyl]- quinazol- 4-one [II] which further reacted with semicarbazide, to afford the corresponding semicarbazone [III]. The latter compound was then subjected to oxidative cyclization either by a SeO2 or SoCI2 to give selena- and thiadiazoles [IV] and [VI], respectively. 2-[2- arylethenyl]- 3-[4-[1, 2, 3-thia and selenadiazol-4-yl] pheny] quinazol-4-one [VII] and [X] were prepared by heating [VI] and [IX] with the aromatic aldehydes. Compound [IV] was condensed with different aromatic amines to yield the corresponding Schiff's bases [V]