RESUMEN
This study revealed a significant reduction of insulin mean values in all diabetic patients. The reduction was more significant in vascular- complicated NIDDM than complicated and in vascular- complicated patients with more than five years disease duration compared with non- vascular complicated patients. Glucagon mean values showed a significant reduction in patients with positive family history, those with less than five years disease duration and in NIDDM patients compared with controls. The vascular complicated IDDM patients showed a significant reduction of the mean level of ACT compared with non-vascular group. Significantly increased mean levels of growth hormone were found in all groups compared with the controls. Significant elevation of prolactin level was observed comparing negative and positive family history and comparing vascular and non- vascular complicated NIDDM patients. Significant reduction of IGF-1 levels was found comparing diabetic patients with controls, patients with less and more than five years disease duration with controls and with those with less than five years duration and comparing IDDM with controls or with NIDDM patients