RESUMEN
Objective: polycystic ovary syndrome [PCOS], an ovarian-pituitary axis androgen disorder, is a common endocrine disease in women. Obesity-induced androgenesis and imbalance of adipokine secretion may lead to some metabolic features of PCOS. The beneficial effects of polyphenolic compounds such as quercetin have been reported, however, the underlying molecular mechanism is not entirely understood. In the present study, we investigated the effect of quercetin supplementation on the expression of adiponectin receptors at the transcript level in peripheral blood mononuclear cells [PBMC] samples of PCOS patients
Materials and Methods: in this randomized clinical trial, 84 PCOS subjects were randomly assigned to two groups; the treatment group received 1 g quercetin [two 500 mg capsules] daily for 12 weeks and the control group received placebo. To examine the effect of quercetin supplementation on PCOS patients in addition to biochemical and anthropometric assessments, the expression of ADIPOR1 and ADIPOR2 at the transcript level and AMPK level were determined by quantitative reverse transcription-polymerase chain reaction [RT-qPCR] and ELISA assays respectively
Results: oral quercetin supplementation significantly increased ADIPOR1 and ADIPOR2 transcript expression by 1.32- and 1.46-fold respecetively [P<0.01]. In addition, quercetin supplementation enhanced AMPK level by 12.3% compared with the control group [P<0.05]
Conclusion: oral quercetin supplementation improves the metabolic features of PCOS patients by upregulating the expression of adiponectin receptors and AMPK [Registration Number: IRCT2013112515536N1]
RESUMEN
Background: Inflammatory bowel disease [IBD], Crohn's disease [CD], and ulcerative colitis [UC] are autoimmune inflammatory diseases of the alimentary tract, which seems to be caused by the interaction of environmental and genetic factors as well as diet and nutritional factors such as vitamin D. The aim of this study was to assess the vitamin D status and its associations with erythrocyte sedimentation rate [ESR], and high-sensitivity C-reactive protein [hs-CRP] as inflammatory markers in patients with UC
Methods: In this analytical cross-sectional study 90 patients with mild to moderate UC who were resident of Tehran were assessed. 25[OH]D, parathyroid hormone [PTH], ESR and hs-CRP were measured. Dietary intake was assessed by 3-day 24h diet recall. Statistical analyses were performed using STATA [Version 12]
Results: The average serum 25-OH-vitamin D3 was 33.1+/-8.3 ng/mL and 38.9 % of the patients were vitamin D deficient or insufficient [37.3 % of men and 41% of women]. No significant correlation between serum 25[OH]D and hs-CRP, ESR, body mass index [BMI], and disease duration was found. There were no significant differences in serum 25[OH]D between men and women. Mean daily dietary vitamin D and calcium intakes were 189.5 Iu [95% CI: 176.0-203.1] and 569.5 mg [95% CI: 538.8-600.2] respectively
Conclusion: In this cross-sectional study 38.9% of the patients with mild to moderate UC were vitamin D deficient or insufficient and vitamin D level was not correlated to ESR and/or hs-CRP. More studies are needed to investigate the effect of vitamin D in the pathogenesis of UC or as a part of its treatment