RESUMEN
Insulin resistant is important risk factors of diabetes and leads to development of chronic diseases such as diabetes and cardiovascular disease. Recent studies showed association between androgenic alopecia and insulin resistant. However, findings are controversial. Alopecia in women is a common heritable hair loss in central part of head. Aim of this study was investigation of androgenic alopecia distribution in type II diabetes and healthy women and hypothesis testing of relationship between diabetes and androgenic alopecia. This is a case-control study. Case and control groups were selected from type H diabetes and healthy women respectively that were refered to clinics of Alzahra, Noor and Amin Hospitals in Isfahan City, Iran in 2011. Participants were selected based on random sampling. Sample size was estimated 141 subjects in each group. Participants were visited by doctor and severity of androgenic alopecia was determined based on Ludwish criteria. Data were analyzed with SPSS software and chi[2] test. P<0.05 was considered as significant. Mean age and body mass index were 58.96+12.8 year and 25.6+4.15 kg/m- respectively in whole population. Findings not show any significant association between type II diabetes and androgenic alopecia [P<0.05]. Comparison of distribution of alopecia severity according to Ludwish criteria separately showed similar result. In addition to, there was not any significant relationship between diabetes and alopecia after adjusting with body mass index as confounding factor [P<0.05]. In the present study, there was not any significant relationship between type II diabetes and androgenic alopecia among diabetes and healthy women. However, more researches need to investigate this relationship in both gender and assess insulin resistant indices as homeostasis model assessment-estimated insulin resistance and androgenic alopecia
RESUMEN
According to several documented usefulness of green tea and importance of healing of open skin wound, this study designed to evaluate effects of watery and alcoholic extracts of green tea on the healing of open skin wounds of NMRI mice. In this experimental study, 56 male NMRIs divided equally in 7 different groups, were studied. Different doses of watery and alcoholic extracts, including 50, 150 and 300 micro L, were injected to 6 experimental groups. After anaesthetizing the NMRIs, skin wound was created on the back of the rats by a 6mm punch. Control group was treated by physiology serum around the wound of the back of each NMRIs. Dimension and also the recovery percent of the wound in the 1st, 3rd, 5th, 7th, 10th, 13th and 15th days of study, were measured. Furthermore, the needful time for recovery was evaluated. Two Specimens of wound skin were supplied in 4th, 7th and 15th days of study for microscopic studies. Fibroblasts, inflammation, epitheleum and endothelial cell of blood vessels from the wounds were studied. Data were analyzed using analysis of variance [ANOVA] method. P<0.05 was considered as significant level. There were no significant differences between three groups of control, watery extract and alcoholic extract groups in recovery processes [NS]. But, mean diameter of wound within 1, 3, 5, 7 and 15 days of study was significantly lower in experimental groups compared with control group [p<0.001]. Degree of fibroblasts, inflammation and epithelium in different days in 6 groups of watery and alcoholic groups was significantly lower than control group [p<0.001]. This study showed that watery and alcoholic extracts of green tea speed up the wound healing in NMRIs and there isn't any difference between the use of watery and alcoholic extracts. But higher dose of injection [300 micro L] is valuable in forming of wound