RESUMEN
The aim of this investigation was to assess the efficacy of hydrochlorothiazide as a hypocalciuric diuretic on stone-free rate of renal pelvic calculi after extracorporeal shock wave lithotripsy [ESWL]. A double-blind, placebo-controlled randomized clinical trial was conducted and 52 patients with renal pelvic calculi [diameter = 2 cm] were enrolled from February 2010 to September 2010. ESWL protocol was performed by 2,500 shocks per session. The patients were randomized into two groups: [1] 26 patients who were given 25 mg hydrochlorothiazide twice daily; and [2] 26 patients who received placebo. The stone-free rate was defined as residual calculus size = 4 mm in controlled ultrasound on 2[nd] week, 1 month and 3 months after ESWL. 1[[78%] of the first group and [[42.[%] of the second group were stone-free after one session of ESWL [P = 0.02]. 88% of the group 1 and 47.8% of the group 2 were stone-free on 1 month after ESWL [P = 0.003]; however, this effect of hydrochlorothiazide was not related to the patients' body mass index, age and gender. The accessory treatment procedures were applied in 24% of the group 1 compared with 1[% of the group 2 during 3 months [P = 0.68]. All patients in both groups were stone-free on 3 months following lithotripsy. Hydrochlorothiazide did not impact on the stone-free rate and using accessory procedure within 3 months; however, it decreased duration of stone-free status and number of ESWL sessions
RESUMEN
PURPOSE: To investigate the prophylactic effect of Tamsulosin, a super-selective alpha-1a adrenergic blocking agent, on the development of urinary retention in men undergoing elective inguinal herniorrhaphy. MATERIALS AND METHODS: From May 2010 through November 2011, a total of 80 males who underwent elective inguinal herniorrhaphy in a university hospital were included in this study. Patients were randomly assigned to one of two groups. In group one (control), the patients were given two doses of placebo orally, 6 hours before surgery and 6 to 12 hours after surgery. Patients in group two were given 0.4 mg of Tamsulosin orally in the same manner as the placebo. All patients were closely followed for 24 hours post-operatively, and any voiding difficulties or urinary retention was recorded. RESULTS: There were 40 patients in group one (control group) and 40 patients in group two (Tamsulosin group). The patients' mean age was 64 years. In group one, 6 patients and in group two, 1 patient required catheterization. Thus, 15% of patients in group I and 2.5% of patients in group II had urinary retention. The difference in the requirement for catheterization was statistically significant (p=0.04). The technique of herniorrhaphy, the side of the body in which the hernia was located, the type of anesthesia, the duration of the surgery, and the severity of pre-operative urinary symptoms had no significant effect on the incidence of urinary retention. CONCLUSIONS: The use of perioperative Tamsulosin represents an effective strategy to reduce the risk of post-operative urinary retention following inguinal herniorrhaphy.