RESUMEN
Background: Hyperuricemia as an independent risk factor of cardiovascular disease or not is debated for years
Objective: To determine the association of high serum uric acid level with acute coronary syndrome [ACS]
Subjects and Methods: This was a case control study, conducted from 1[st] January to 31[st] August, 2014, in Department of Cardiology, Sheikh Zayed Medical College/Hospital, Rahim Yar Khan. A total of 367 study subjects, with 193 patients taken as cases, having acute coronary syndrome [ACS], diagnosed and labeled after thorough relevant investigations and 174 controls do not having acute coronary syndrome, selected from accompanying attendants, were included in study. The variables included in study were age, sex, BMI, hypertension, smoking, serum cholesterol, HDL, LDL, triglyceride, serum uric acid level and disease status of ACS. Serum uric acid >7mg/dl in males and >6mg/dl in female was taken as high. Informed verbal consent was taken from all the cases and controls before including them in study. The data was entered and analyzed in SPSS version 16
Results: A total of 367 study subjects, with 193 patients having coronary heart disease and 174 controls do not having coronary heart disease, were included in study. The mean age of patients of ACS was 52 +/- 11 years, versus controls 47 +/- 15 years, 84% among patients of ACS versus 75% among control were male, BMI was 27 +/- 3 among patients of ACS versus 25 +/- 6 among control, HDL was 41.92 +/- 8mg/dl among patients of ACS versus 43 +/- 6mg/dl in controls, triglyceride was 172.68 +/- 98mg/dl among patients versus 168 +/- 78mg/dl in controls, LDL was 119 +/- 37mg/dl among patients versus 118 +/- 32mg/dl in controls, and serum uric acid was 6.1 +/- 1.2mg/dl among patients versus 5.1 +/- 0.3mg/dl in controls. Those who have ACS, 37.3% have high serum uric acid as compared to 24% among Non CHD subjects. [p-value 0.00]
Conclusion: This study showed that elevated serum uric acid level was statistically significantly associated with Acute Coronary Syndrome