RESUMEN
Objective: To determine the association between serum 25 hydroxyvitamin D levels and percent breast density among asymptomatic premenopausal women
Methods:Hundred asymptomatic, pre-menopausal women who visited the General Surgery Breast Clinic, Patel Hospital, Karachi, Pakistan between 3rd March and 10th November, 2015 were included in this study. The serum 25 [OH]D and calcium levels were measured and mammographic density [MD] was assessed using automated volumetric breast density software, Volpara Research [algorithm version 1.5.1, Volpara solutions Ltd, Wellington, NZ] on the same day. The volumetric breast density [VBD] was categorized as; VG1: 0% - 4.5 %; VG2: 4.6% - 7.5%; VG3: 7.6% - 15.5% and VG4 >15.5%. Mean serum 25[OH]D and calcium levels were compared across the four volumetric breast density categories. The percent volumetric density was also correlated with anthropometric measurements and other related variables
Results:No significant difference was found in mean serum 25 [OH]D level across the four groups [15.87 Vs. 12.40 Vs. 8.99 Vs. 9.68; p-value = 0.106]. The percent VBD were found significantly negatively correlated with age [r = - 0.365; p-value = 0.001], weight [r = - 0.575; p-value = 0.001], height [r = - 0.197; p-value = 0.049], and BMI [r = - 0.519; p-value = 0.001]. The serum Vitamin D, and calcium levels were not found significantly correlated with percent VBD [p-value > 0.05]
Conclusion:No significant association exists between serum 25[OH]D level and breast density