RESUMEN
Treatment with doxorubicin [DOX] is a common treatment for different types of cancer. DOX-NP is one of a well established marketed liposomal formulation for DOX. It has advantages over free DOX in reducing the cardiac toxicity and increasing the efficacy. Gold nanoparticles [GNPs], have been widely used in biomedical applications such as medical imaging and biosensors. Mice bearing Ehrlich tumor were injected with saline, free doxorubicin [DOX] in solution, gold nanoparticles loaded liposomes and commercial liposomal encapsulated doxorubicin [DOX-NP]. The results showed that GNPs loaded liposomes could enhance the antitumor activity of commercial liposomal formulation [DOX-NP] and displayed significantly decreased systemic toxicity compared with free DOX and commercial liposomal formulation [DOX-NP] at the equivalent dose. So the injection of GNPs and DOX-NP is expected to increase the cell killing and make it a promising approach to cancer treatment