RESUMEN
Objective: To investigate the role of oxidative stress in patients with senile cataract
Study Design: Case-control study
Place and Duration of Study: North Khorasan University of Medical Sciences, Bojnurd, Iran, from 2014 to 2015
Methodology: Non-randomised sampling was conducted on 74 patients with senile cataract and 79 healthy people. The oxidative stress level, glutathione peroxidase [GPx] and superoxide dismutase [SOD] enzymes were measured in serum. The results were analysed using SPSS software and followed by t-test analysis. P<0.05 was considered to be significant
Results: The median activity of GPx and SOD antioxidant enzymes in patients with cataract, was higher than healthy people [p=0.018 and p<0.0001, respectively]. Peroxide-antioxidant [PAB] levels in patients with cataract was significantly higher than in healthy people [p<0.0001]
Conclusion: This study showed that despite the high level of oxidative stress in patients, the activity rate of GPx and SOD enzymes also increased