Lipoid proteinosis: clinical, histopatthological and ultrastructural study

This study demonstrated the reduplication of basal laminae of basement membrane zone and thickened papillary dermis with a marked deposition of hyaline-like material interspersed between thin separated collagen fibrils. Immediately surrounding the blood vessel walls, hyaline deposits were seen together with the reduplication of basal laminae in an onion-like arrangement. The fibroblasts, epithelial cells of eccrine sweat glands and dermal histiocytes showed vacuolated cytoplasm with several types of lysosomes, i.e. empty with curved tubular profiles or farber-like inclusions. Some dermal nerve endings showed dystrophic axons with multiple dense laminated bodies in axoplasm

Expression of p53 protein and evaluation of proliferative activity by Ki-67 in skin tumours

The immunohistochemical detection of Ki-67 as an indication of proliferative activity and p53 protein overexpression was investigated in 37 skin lesions and tumors. The mean Ki-67 proliferation index [PI] was low in normal skin control biopsies as well as in seven benign lesions including seborrheic keratosis [SK] and verruca vulgaris [VV]. Squamous cell carcinoma [SCC] showed the highest PI. The different proliferation rates of BCC and SCC were of the factors explaining their variable biologic behavior. P53 overexpression was common in skin tumors and can be used to detect malignant potential of AK. P53 alterations may contribute to the development of KA, but the detection of p53 protein was inadequate for the distinction between SCC and KA