RESUMEN
Ibuprofen controlled release granules were prepared by either pan coating or solid dispersion technique. In the first case, ibuprofen core granules were coated with different ratios of certain polymers; namely, ethyl cellulose, Eudragit RS 100 and 1:1 mixture of both polymers. The process of pan coating was continued until the weight of the granules has increased by 20, 30 and 40% for each type of polymers. In the second case, coprecipitates of ibuprofen were prepared by solvent evaporation technique using the same polymers in ratios 3:1, 2:1 and 1:1. The adhered drug and microencapsulated drug were determined and the coated granules were evaluated for angle of repose, flow rate, bulk density, Hausner factor, compressibility and drug content and dissolution. The coprecipitate was evaluated for drug content and dissolution. Both coated granules and coprecipitate were evaluated for ulcerogenic activity using albino rats