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Abstract Currently, there is a paucity of available treatment strategies for oxidative phosphorylation disorders. Coenzyme Q10 (CoQ10) and related synthetic quinones are the only agents to date that have proven to be beneficial in the treatment of these heterogeneous disorders. The therapeutic efficacy of CoQ10 is not restricted to patients with an underlying CoQ10 deficiency and is thought to result from its ability to restore electron flow in the mitochondrial respiratory chain (MRC) as well as to increase the cellular antioxidant capacity. At present, however, there is no consensus on the appropriate dosage or therapeutic plasma level of CoQ10, and this information will be required before CoQ10 can be utilized effectively in the treatment of mitochondrial disease. The following review will outline our current knowledge on the use of CoQ10 in the treatment of MRC disorders and primary CoQ10 deficiencies.
RESUMEN
INTRODUCCIÓN: el tratamiento protético con obturadores en pacientes con defectos maxilares, ya sea por causa oncológica o por defectos congénitos, debe devolver las funciones importantes, como deglución, fonación, masticación, además de una estética aceptable, ya que la apariencia personal puede hallarse tan afectada, que la rehabilitación estética resulta más necesaria y urgente que la misma rehabilitación funcional. OBJETIVO: valorar la repercusión de la rehabilitación con prótesis obturatriz en pacientes adultos atendidos en el Centro de Rehabilitación de la Cara y Prótesis Bucomaxilofacial entre los años 2004 y 2009. MÉTODOS: se desarrolló la investigación en servicios de salud sobre la base de un estudio descriptivo, transversal con enfoque cuantitativo. El universo estuvo constituido por 215 pacientes; la muestra se conformó al azar con 31 pacientes encuestados durante el 2011. RESULTADOS: predominaron el sexo femenino, el grupo de 35-59 años de edad y los defectos grandes de causa oncológica. Se restableció la estética en la mayoría de los pacientes, tanto de causa oncológica como congénita. Los factores funcionales analizados se comportaron de manera adecuada. La mayor parte de los pacientes se encontraban satisfechos con relación al uso de la prótesis obturatriz y al servicio recibido, pues lograron sus expectativas. CONCLUSIÓN: la repercusión de la rehabilitación con prótesis obturatriz se valoró de medianamente positiva en los pacientes estudiados.
IINTRODUCTION: prosthetic treatment by means of obturators in patients with maxillary defects, due to oncologic reason or congenital defects, should restore the most important functions like deglutition, phonation, mastication, as well as, an acceptable aesthetics, because personal appearance can be affected in a sense that, aesthetic rehabilitation is more necessary and urgent than functional rehabilitation in itself.Objective: to evaluate the repercussion of rehabilitation with opturator prosthesis in adult patients treated on the Buccal and Maxillofacial Prosthetics Center from 2004 to 2009. METHODS: a descriptive and transversal research with a quantitative approach was carried out in health services. The universe was constituted by 215 patients; 31 patients interviewed during 2011 were randomly taken as sample. RESULTS: female sex, people in the age range 35-59 years and large defects of oncologic cause predominated. Aesthetics was reestablished in the majority of patients, as much as, oncologic cause, as congenital one. The analyzed functional factors manifested adequately. Most of the patients felt satisfied and achieved their expectations in relation to the use of the obturator prosthesis and the service received. CONCLUSION: repercussion of the rehabilitation with obturator prosthesis was evaluated of moderately positive in the studied patients.