RESUMEN
Patients with systemic lupus erythematosus (SLE) are at higher risk for malignant lymphomas, among which, however, primary CNS lymphoma (PCNSL) is rare. PCNSL usually occurs within the cerebral hemispheres, occasionally in the cerebellum, but rarely in the cerebellopontine angle (CPA). We report our findings in a 45-year-old man with SLE on azathioprine, who presented with sudden hearing loss and dysphagia. The brain MRI revealed a mass lesion in the right CPA. A biopsy was performed and the final diagnosis was diffuse large B cell lymphoma. This is the first report of CPA lymphoma in a SLE patient. The patient was treated with whole brain radiotherapy only because of recurrent pneumonia that was a result of dysphagia from permanent cranial nerve injury. He has been in complete remission for over 10 months.
Asunto(s)
Humanos , Persona de Mediana Edad , Azatioprina , Biopsia , Encéfalo , Ángulo Pontocerebeloso , Cerebelo , Cerebro , Traumatismos del Nervio Craneal , Trastornos de Deglución , Diagnóstico , Pérdida Auditiva , Pérdida Auditiva Súbita , Lupus Eritematoso Sistémico , Linfoma , Linfoma de Células B , Imagen por Resonancia Magnética , Neumonía , RadioterapiaRESUMEN
In recent years, the synchronous occurrence of two adjacent but histologically distinct tumors arising in the same organ has been reported. The simultaneous development of gastric adenocarcinoma and gastrointestinal stromal tumor (GIST) is very uncommon. The question raised was whether such a coexistence is a simple incidental finding or whether the two neighboring tumors are caused by a same unknown carcinogenic agent. Many doctors may have an interest in this rare condition and we expect further studies will be done in order to determine if there is any association between the two different tumors. We report a unique case of a synchronous, orthotopic occurrence of an early gastric cancer with GIST in the same location that mimicked advanced gastric cancer.