RESUMEN
Background: Infertility is defined as a lack of conception in a coupIe having unprotectes intercourse, for one year. Despite enormous progresses in the understanding of human reproductive physiology, the underlying causes of male infertility remains undefined in about 50.0% of cases, which are referred to as idiopathic infertility
Human apurinic/apyrimidinic endonuclease [ApEl] is a multifunctional protein that has an important role in the base excision repair [BER] pathway. ApEl -141 T>G polymorphism is located in the promoter region
The aim of this study was to investigate the relation between ApEl -141T>G polymorphism and idiopathic male infertility
Methods: hi this case-control study, Samples were collected from 90 patients diagnosed with idiopathic male infertility and also from 60 control subjects. Collected samples were genotyped by allele-specific PCR [AS-PCR]
Results: There was significantly association between -141TX/] polymorphism and idiopathic male infertility [p=0.022]
Conclusion: The polymorphism 141T>G can be associated with male infertility. However, further studies are needed to confirm the results