effect of modified Lytic cocktail mixture on hyperpyrexia

This study was done on thirty adult febrile patients with different age. weight and sex and with different infectious aetiologies to evaluate the effect of [modified lytic cocktail mixture] a combination of promazine, pethidine and hydergine to assess their role on hyperpyrexia The results showed that the lytic cooctkail have significant effect on hyperpyrexia and that the combination of promazine, pethidine and hydergine was very excellent in lowering body temperature in this type of fever in short time [8 +/- 1.5 hours] and may be useful when urgent need to decrease body temperature is desired. They also decreased the PCO2, with no effect on haemodynamics and significant improvement in state of body oxygenation