RESUMEN
BACKGROUND: The function of the p53 protein is known to regulate cell proliferation by inhibiting cells entering S phase, so DNA damaged cell proliferation is inhibited by apoptosis. p21 is a cyclin dependent kinase inhibitor induced by wild type p53, not mutant p53. Thus p21 is thought to mediate the signal of p53 induced by DNA damaged agents to arrest the cell cycle in G1 phase. p53 and p21 are expressed in many malignant tumors, and its role in oncogenesis, tumor progression and prognosis are important. OBJECTIVE: The purpose of this study was to analyze immunohistochemical expression of mutant p53 and p21 protein in melanocytic lesions. METHOD: 11 cases of intradermal nevus, 7 cases of junctional nevus and 6 cases of malignant melanoma were immunohistochemically stained with p53 and p21 monoclonal antibodies. RESULTS: 1. In intradermal nevus, the p53 was negative in 100% and the p21 was negative in 98%. These findings suggest that the composing cells of intradermal nevus is completely mature cell. 2. The positive rates of p53 and p21 in junctional nevus were 43% and 43%, respectively. The positive rates of p53 and p21 in malignant melanoma were 82% and 67%, respectively. CONCLUSION: If the expression of p21 is induced by p53 independent pathway, the cell cycle can be arrested in G1 phase, so the tumor cell proliferation is inhibited. But if the expressed p21 is mutated as p53, it means that the natural function of p21 disappears. More research is necessary about the nature of p21 which is expressed with mutant p53.
Asunto(s)
Anticuerpos Monoclonales , Apoptosis , Carcinogénesis , Ciclo Celular , Proliferación Celular , Ciclinas , ADN , Fase G1 , Melanoma , Nevo , Nevo Intradérmico , Fosfotransferasas , Pronóstico , Fase SRESUMEN
We report a case of type IIb hyperlipoproteinemia associated with xanthoma tuberosum, xanthoma planum and xanthoma striatum. Serum lipoprotein electrophoresis showed increased beta fraction and pre-beta fraction, suggesting type IIb hyperlipoproteinemia.
Asunto(s)
Electroforesis , Hiperlipoproteinemias , Lipoproteínas , Temazepam , XantomatosisRESUMEN
A 30-year-old man presented with several intensely prurutic erythematous serpiginous thread-like skin lesions which began as a small papule on the upper back 2 weeks prior to his visit and was migrating to the lower back and buttock area. The laboratory examination showed non-specific findings. Histopathologic examination revealed a pustular burrow containing numerous eosinophils in the epidermis. In the dermis, there was a diffuse and occasionally dense perivascular inflammatory cell inflammation consisting of eosinophils and some lymphocytes. The patient was treated with oral albendazole, antihistamine and topical corticosteroid for 2 weeks without recurrence for 6 months up to now. Multiple histologic sections were made without success in demonstrating parasitic tissue in the epidermis, however, the clinical and histopathologic features were consistent with cutaneous larva migrans.
Asunto(s)
Adulto , Humanos , Albendazol , Nalgas , Dermis , Eosinófilos , Epidermis , Inflamación , Larva Migrans , Linfocitos , Recurrencia , PielRESUMEN
Subungual exostosis is an uncommon benign tumor of cartilaginous bone arsing adjacent to the distal phalanx of a digit. It is usually a solitary lesion that develops most often in substance of the great toe and less frequently in other toes. The rare presentation of subungual exostosis in a finger usually stimulates an extensive differential diagnosis. We present a case of subungual exostosis of the finger in a 54-year-old female. Roentgenographic findings showed stick-like calcified density on the tip of the distal phalanx of the left 5th finger. Histopathologic findings showed enchondral bone structure and surroundung cartilaginous tissues in the dermis. At 6-month follow-up, the result was excellent, with no sign of recurrence.
Asunto(s)
Femenino , Humanos , Persona de Mediana Edad , Dermis , Diagnóstico Diferencial , Exostosis , Dedos , Estudios de Seguimiento , Recurrencia , Dedos del PieRESUMEN
We describe an 11-year-old male who developed recurrent pyogenic granuloma with satellitosis in the scapular region after surgical excision of a solitary pyogenic granuloma. This is a well-recognized but rare event. Histologic findings showed many newly formed capillaries that had prominent endothelial cells, and varying degrees of dilation without appearance of epidermal collarette sign. We report a case that the satellite lesions were removed by carbon-dioxide laser excision.
Asunto(s)
Niño , Humanos , Masculino , Capilares , Células Endoteliales , Granuloma PiogénicoRESUMEN
Bleomycin, an antitumor antibiotic, has several dose-related skin toxicities, including hyperpigmentation, sclerosis, gangrenes, nail changes, and erythema in certain selected skin sites. A case of hyperpigmentation in a linear pattern due to in tavenous injection of bleomycin in a 37-year-old man with squamous cell carcinoma at nasopharynx is described. After 9 months since bleomycin chemotherapy started, dark brownish colored linear hyperpigmentation developed along veins of the skin of both arms.
Asunto(s)
Adulto , Humanos , Brazo , Bleomicina , Carcinoma de Células Escamosas , Quimioterapia , Eritema , Gangrena , Hiperpigmentación , Nasofaringe , Esclerosis , Piel , VenasRESUMEN
Kerion celsi is an inflammatory type of tinea capitis and presents an inflammatory, boggy mass studded with broken hairs, oozing purulent material from follicular orifices. But it occurs usually in children and rarely in normal, healthy adults. We present an unusual case of kerion celsi caused by M. canis in a 69-year-old woman.
Asunto(s)
Adulto , Anciano , Niño , Femenino , Humanos , Cabello , Microsporum , Tiña del Cuero CabelludoRESUMEN
Microsporum canis is one of the zoophiles and pets(especially dogs and cats) play a role as a source of this organism. M. canis is most likely transmitted by contact of these animal hosts with humans. We report on 16 foreigners who are infected with M. canis transmitted from a show tiger. Fourteen of the patients had directly contact with a show tiger on occasion. Patients showed typical tinea corporis lesions on the extremities, and the tiger showed hairless patches on the abdomen. The culture and microscopic findings from patients' lesions revealed M. canis as the causative fungus.
Asunto(s)
Animales , Perros , Humanos , Abdomen , Emigrantes e Inmigrantes , Extremidades , Hongos , Microsporum , Tigres , TiñaRESUMEN
Squamous cell carcinoma(SCC) is a recognized late complication of chronic discoid lupus erythematosus(CDLE). There are many case reports of SCC in white patients with chronic DLE. However, it is uncommon in blacks and Asians. The etiology of squamous cell carcinoma is multifactorial. The predisposing factors for the development of SCC in these patients include actinic keratosis, Bowen's disease, burn scars, arsenic keratosis, and chronic discoid lupus erythematosus. Of these causes, SCC developing in the lesions of CDLE is very rare. We report a patient who has been evaluated for ten years with a diagnosis of discoid lupus erythematosus and has squamous cell carcinoma.