RESUMEN
Objectives: To determine the relationship of total cholesterol, HDL-C and their ratio among ischemic and hemorrhagic stroke
Study Design: An observational prospective comparative study
Place and duration: This research work was carried out from 1[st] June 2014 to 31[st] December 2014 at department of medicine Bahawal Victoria Hospital Bahawalpur
Methedology: Hundred patients between 30 to 90 years of age, who were admitted by the department of general medicine BVH Bahawalpur with first ever stroke and verified by CT scan brain, were included in the study. Patients who had history of coronary heart disease or lipid lowering drugs, neurological deficits secondary to epilepsy, infective or metastatic disorder, or pre-existing severe cognitive disorder were excluded from this study. A detailed history and physical examination details along with fasting lipid profile were collected from patient records in the hospital medical department. Mean values of quantitative data were presented as mean SD [standard deviation].Frequency percentage of total cholesterol, high density lipoproteins and triglycerides in both groups of ischemic and hemorrhagic stroke, were determined and compared using proportion test for any significant difference taking p-value of < 0.05 as significant
Results: Quantitative data of CVA, comprising [50 each of ischemic and hemorrhagic cases] was analyzed. Mean age of presentation was 56 years. In 50 ischemic patients mean total cholesterol was raised above normal reference range. It was 218.30 +/- 79mg/dl in ischemic stroke while it was 194 +/- 26.7mg/dl in hemorrhagic cases and it was highly significant at P value of < 0.001.The mean HDL concentration was 33.10 -7.33 in patients of ischemic stroke while it was 39.02-4.22 in hemorrhagic cases with p value of o.oo2 [highly significant]. Serum triglycerides levels turned out to be normal in both groups
Conclusion: Hypercholesterolemia and low HDLC was seen significantly in ischemic CVA group as compared to hemorrhagic counterpart
RESUMEN
Diabetes mellitus, hypertension, obesity and dyslipidemia are the integral components that constitute metabolic syndrome. It has emerged as cause of substantial mortality with gender difference. To compare the gender characteristics of metabolic syndrome in subjects of type 2 diabetes mellitus. This observational comparative prospective study was conducted in medical ward of BVH Bahawalpur over period of 6 month from January 2014 to June 2014. Sample size of 100 diagnosed cases of type 2 diabetics [comprising equal number of males and females] were collected. As defined by WHO and IDF, variables of metabolic syndrome studied were BMI, hypertension, hyperglycemia and hyperlipidemia. The lipid values were interpreted in normal or high risk category by applying NCEP ATPIII criterion. Fasting sample were collected for sugar and lipid profile. Anthropometric, demographic and biochemical data was tabulated. Continuous and categorical variables were displayed as mean +/- standard deviation and percentage respectively. Student 't' test was use to assess the difference for the lipid profile at 5% significance level. Female patients were found to be overweight, hypertensive and had uncontrolled hyperglycemia as compared to male subjects. Their systolic blood pressure was 150 +/- 25.75 and diastolic was 90 +/- 17mm/hg. The mean blood glucose concentration was 246.64 +/- 105mg/dl. In age group 35-44 years, the mean triglycerides and cholesterol levels in females were 184.54 +/- 42.05 and 192.5 +/- 34mg/dl respectively. HDL-C was 33.2 +/- 5.19mg/dl. In females with age group of 45-54 years, the mean concentration of triglycerides, total cholesterol and HDL-C were 217.75 +/- 77.6mg/dl, 190.95 +/- 14.4mg/dl and 31.75 +/- 3.8mg/dl respectively, and all were in high risk category when compared to cut off values determined by NCEP/ADA. While in females of age group 55-64 years, the values of TGs, total cholesterol and HDL-C were 204 +/- 154.11mg/dl, 200.09 +/- 47.8 mg/dl and 33.4 +/- 4.6mg/dl respectively and again all these values were significantly raised. Female genders were affected in all respects. They had higher BMI, hypertension, hyperglycemia and hyperlipidemia as compared to male counterparts
RESUMEN
Objectives: To assess and compare the HDL Cholesterol among male and female type 2 diabetics and to look for the blood pressure and glycemic stats between both genders
Study design: An observational comparative prospective study
Place and duration: The study was conducted in Medical Unit-2 of Bahawalpur Victoria Hospital over a period of 6 months from June 2012 to December 2012
Methodology: A sample size of hundred diagnosed cases of type 2 diabetes was collected. Those who had hyperlipidaemia due to secondary causes like nephrotic syndrome, hypothyroidism and drugs were excluded. Fasting blood samples were collected for sugar and lipid profile. All collected data was analyzed through software SPSS version 10
Results: Female patients were found to be overweight and hypertensive and they had uncontrolled hyperglycemia as well. The mean values of lipoprotein were deranged in females as compared to males. By applying NCEP ATP III criterion, lipid level were classified into different risk categories. In female patient the mean concentrations of HDL-C was 32+2.4mg/dL [T-Value = -23.57 very highly significant] and was in high risk category while LDL-C was 191+31.81mg/dL [T-Value = -2.01 significant] and was in borderline risk. LDL: HDL ratio was 6.0 and significantly raised. Triglycerides were within normal range. In male patients the mean concentration of LDL was borderline risk 174+41mg/dL [T-Value = 13.2] while HDL-C was 40mg / dL [T-Value = -6.53], both in borderline category. LDL: HDL ratio was also in acceptable range in males. Triglycerides values turned out to be within normal range in both gender
Conclusion: HDL cholesterol was frequently reduced and was in high risk category in female diabetic patients as compared to male counterparts and LDL values were borderline. Hence they are at more risk of complications as they were hypertensive and had more uncontrolled hyperglycemia as well