Effects of L-carnitine; on skeletal muscle of rabbit

L-carnitine [L-car] is a trimethylated amino acid required for the transformation of long chain free fatty acids into acylcarnitine and their subsequent transport into the mitochondrial matrix. It enhances the fatty acid oxidation for energy thus delaying the skeletal muscle fatigue. Objectives of this study were to determine effect of L-carnitine supplementation on skeletal muscle lactate after fatigue, to observe effect of L-carnitine supplementation on force of contraction in skeletal muscle and to estimate the time to onset of fatigue after L-carnitine supplementation. In control group, the rabbit sedated and soleus muscle was excised, Homogenized and centrifuged. Supernatant collected, was mixed with reagents of lactate test kit. Absorbance of light was read with the help of spectrophotometer and readings were noted. In experimental group, L-carnitine was given in a dose of 80mg / kg. The period of administration was two weeks. Soleus muscle was excised after giving the last dose of L-carnitine. Lactate level was measured by using lactate test kit [Randox®]. Readings for lactate measurement were noted after fatigue in both groups. Statistically significant results [p <0.05] were found in all three variables. Data was analyzed by applying [t] test in IBM SPSS Statistics - 20 software. L -carnitine delays the onset of fatigue of skeletal muscle. This was the stated alternative hypothesis

Typhoid and non-typhoid ileal perforation: surgical experience of 50 cases

The objective of the study was, to find out the frequency of typhoid and non typhoid ileal perforation, to observe the association of various epidemiological factors in causation of disease and to note surgical, clinical, and laboratory findings along with mortality. A comparative descriptive study. The study was conducted in the department of surgery Civil Hospital Karachi from June 1997 to August 1998. fifty consecutive patients of non-traumatic ileal perforation managed surgically were observed by making two groups of typhoid and non typhoid ileal perforation. Out of 50 [n=50] 32 [Group - A] patients [26 male and 6 female] had typhoid while 18 [Group - B] patients [15 male and 3 female] had non-typhoid ileal perforation. There were 41 [82%] male and 09 [18%] female. In-group A age range was 16-50 years and a mean of +/- SD of 25 +/- 10 while in group B age range was 12- 60 years and a mean of +/- SD of 26 +/- 11.65. In group A 90.6% while in group B 100% patients had a single perforation. Wound infection was the most common complication. Mortality was 6.25% and 5.5% in group A and B respectively. There was no significant association [P<0.05] of gender, seasonal and living conditions. Surgical cum Epidemiological findings point out to the need of distinguish between different types of non traumatic ileal perforation, and having check on the related causative factors leading to their occurrences

Inverted Meckel's diverticulum causing intussusception in an adult

Adult intussusception is rare, making-up only about 1% of the causes of bowel obstruction intussusception, secondary to an inverted Meckel's diverticulum, is also a rare occurrence. Chronic abdominal pain, lower gastrointestinal bleeding, and recurrent obstructive symptoms may lead to an unnecessary delay in diagnosis. This case report describes a rare cause of adult intestinal intussusception due to inverted Meckel's diverticulum. Intussusception was diagnosed on emergency ultrasound of the patient, who was successfully managed with surgery