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Transcranial Doppler (TCD) is a method for measuring cerebral artery blood flow velocity, which has the advantages of low cost, non-invasive, high temporal resolution. Dynamic cerebral autoregulation (dCA) is to study the instantaneous change of cerebral blood flow (CBF) at the moment of arterial blood pressure or intracranial pressure change, that is, the ability to recover CBF in the face of sudden change of perfusion pressure. After the onset of acute ischemic stroke (AIS), effective dCA can maintain the stability of cerebral hemodynamics and avoid excessive or insufficient perfusion at the injured site. Therefore, it is of great significance to evaluate dCA in patients with AIS. However, at present, there is no recognized optimal evaluation method for dCA. This article mainly summarizes the advantages of TCD in evaluating dCA compared with other methods and the application of TCD combined with transfer function analysis (TFA) in evaluating dCA in AIS.
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@#To explore the correlation analysis between the changes of cognitive function and the expression levels of serum ICAM-1 and 8-iso-PGF2α in patients with acute ischemic stroke. Method A total of 100 patients with Acute ischemic stroke admitted to our hospital from August 2017 to October 2019 were divided into group A （60 cases，MoCA score<26 points） and group B （40 cases，MoCA） according to the MoCA score Score ≥26 points）. Enzyme-linked immunosorbent assay was used to determine the expression levels of ICAM-1 and 8-iso-PGF2α in the two groups. Spearman was used to analyze the correlation between serum ICAM-1 and 8-iso-PGF2α and MoCA scores. Logistic regression was used to analyze Acute ischemic stroke. Influencing factors of patients’ cognitive function changes. ROC curve analysis of serum ICAM-1，8-iso-PGF2α expression for the diagnostic value of cognitive function in patients with Acute ischemic stroke. Results The expression of serum ICAM-1 and 8-iso-PGF2α in group A was significantly higher than that in group B （P<0.05）；Serum ICAM-1 and 8-iso-PGF2α expression levels were significantly correlated with the location of infarct，carotid atherosclerosis，carotid stenosis，NIHSS score，MoCA，and age （P<0.05），but not related to education level （P> 0.05）. The infarcts were located in the thalamus，temporal lobe and frontal lobe. NIHSS score，diabetes and hypertension were independent risk factors for cognitive dysfunction in patients with Acute ischemic stroke （P<0.05）. The sensitivity and specificity of ICAM-1 and 8-iso-PGF2α in diagnosing the changes of cognitive function in patients with Acute ischemic stroke were 93.00% and 90.00% （P<0.05）. Conclusion The expression of serum ICAM-1 and 8-iso-PGF2α is closely related to the changes of cognitive function in patients with Acute ischemic stroke.
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Polycythemia vera (PV) and essential thrombocythemia (ET) are the two most common subtypes of myeloproliferative diseases. Recent studies have shown that cerebral thrombosis is one of the major complications of PV and ET, which is closely related to the poor outcomes of patients. Meanwhile, PV and ET also increase the risk of recurrent cerebrovascular events in patients with cerebral thrombosis. This article reviews the research progress on the correlation between PV and ET and cerebral thrombosis, in order to provide the basis for clinical prevention and treatment of PV and ET.
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Homocysteine (Hcy) is a sulfur-containing metabolic intermediate of methionine,which is normally at a lower level in the blood.Recent studies have shown that the elevated blood level of Hcy is an independent risk factor for ischemic stroke and increases the risk of occurrence of cerebral small vessel disease (CSVD).This article reviews the relationship between Hcy and CSCD.
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Atrial fibrillation is a common type of arrhythmia. Cerebral microbleeds (CMBs) are a neuroimaging phenotype of cerebral small vessel disease, which is related to the tendency of intracranial hemorrhage. Studies have shown that the detection rate of CMBs in patients with atrial fibrillation is higher, and CMBs are also a risk factor for increasing the risk of stroke in patients with atrial fibrillation and death in patients with atrial fibrillation complicated with stroke. This article reviews the predictive factors of CMBs in patients with atrial fibrillation.
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Studies have shown that gap junction (GJ) of astrocytes plays an important role in ischemic brain injury.Therefore,GJ may become a new target for the treatment of ischemic brain injury.In recent years,although the relationship between GJ of astrocytes and ischemic brain injury has been extensively studied,the conclusions are not consistent.This article reviews the structure,distribution,function of GJ,and its research progress related ischemic brain injury.
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A growing number of studies have shown that chronic heart failure is a risk factor for stroke.It can influence the prognosis of patients with stroke,increase mortality,morbidity,and recurrence rate of stroke.However,at present the studies about the correlation between heart failure and ischemic stroke are rare.This article reviews the advances in research on chronic heart failure and ischemic stroke.
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Myocardial infarction and ischemic stroke share many common risk factors.Their pathophysiological processes are also similar and the 2 diseases often occur at the same time.Coronary artery disease is one of the important causes of embolic stroke in the elderly population.However,there are a few reported stroke events available after myocardial infarction.This article reviews ischenic stroke following acute myocardial infarction.