RESUMEN
To understand the roles of two well known tumour suppressor genes. l(2)gl and l(2)gd in normal imaginal disc development in Drosophila, we have initiated a study to examine effect of mulations of these genes on the expression of genes involved in the patterning of the imaginal discs. In this study we show that the expression of wingless, the Drosophila orthologue of the mammalian oncogene Wnt, is affected in the imaginal discs of l(2)gl4 and l(2)gd1 mutant individuals. In the tumourous wing imaginal discs from l(2)gl mutant larvae, the pattern of wingless expression was progressively disrupted with an increase in the area of expression, Tumourous wing imaginal discs from l(2)gd homozygous individuals exhibited progressive broadening and extension of the wingless expressing domains. We suggest that l(2)gl and l(2)gd might be involved in regulating post embryonic expression of Wingless.
To understand the roles of two well known tumour suppressor genes. l(2)gl and l(2)gd in normal imaginal disc development in Drosophila, we have initiated a study to examine effect of mulations of these genes on the expression of genes involved in the patterning of the imaginal discs. In this study we show that the expression of wingless, the Drosophila orthologue of the mammalian oncogene Wnt, is affected in the imaginal discs of l(2)gl4 and l(2)gd1 mutant individuals. In the tumourous wing imaginal discs from l(2)gl mutant larvae, the pattern of wingless expression was progressively disrupted with an increase in the area of expression, Tumourous wing imaginal discs from l(2)gd homozygous individuals exhibited progressive broadening and extension of the wingless expressing domains. We suggest that l(2)gl and l(2)gd might be involved in regulating post embryonic expression of Wingless.