Effects of Solanum lycopersicum L. (tomato) against isoniazid and rifampicin induced hepatotoxicity in wistar albino rats

Abstract Anti-tuberculosis drugs are reported to cause hepatotoxicity, which varies from asymptomatic rise of the hepatic enzymes. Hepatoprotective plants plays important role to protect liver. This study investigated the hepatoprotective potential of the Solanum lycopersicum in rats intoxicated with Isoniazid and Rifampicin (INH+RIF) to induce hepatotoxicity. Thirty wistar albino rats were divided into five groups of six animals each. Group 1 rats were kept control while groups II, III, IV and V were administered with INH+RIF (75+150 mg/kg) orally, for seven consecutive days. For treatment, rats in group III received silymarin while animals in group IV and V were provided with 40 mg/kg and 80 mg/kg of Solanum lycopersicum extract, respectively. On day 0 and 8th blood samples were collected for the analysis of hepatic biomarkers. The data were subjected to one-way ANOVA and Bonferronis post hoc test for statistical analysis. Hepatotoxicity induced by INH+RIF resulted in significant elevation of serum hepatic enzymes including Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), Alkaline phosphatase (ALP), and total bilirubin while decreased the albumin level. The Solanum lycopersicum at dose of 80 mg/kg significantly reduced the hepatic enzymes AST, ALT, ALP and bilirubin while the albumin level was significantly increased. The treatment had non-significant effect on body and liver weight. Drug induced hepatotoxicity can be effectively treated with Solanum lycopersicum at 80 mg/kg dose.

Resumo As drogas antituberculose são relatadas como causadoras de hepatotoxicidade, ocasionando o aumento assintomático das enzimas hepáticas. As plantas hepatoprotetoras desempenham um papel importante na proteção do fígado. Este estudo investigou o potencial hepatoprotetor de Solanum lycopersicum em ratos que foram intoxicados com isoniazida e rifampicina (INH + RIF) para induzir hepatotoxicidade. Trinta ratos wistar albinos foram divididos em cinco grupos de seis animais cada. Os ratos do grupo 1 representaram o grupo controle, enquanto os ratos dos grupos II, III, IV e V receberam INH + RIF (75 + 150 mg/kg) por via oral, por sete dias consecutivos. Para o tratamento, os ratos do grupo III receberam silimarina, enquanto os animais do grupo IV e V receberam 40 mg/kg e 80 mg/kg de extrato de S. lycopersicum, respectivamente. Nos dias 0 e 8, foram coletadas amostras de sangue para análise de biomarcadores hepáticos. Os dados foram submetidos a teste unilateral (ANOVA) e post hoc de Bonferroni para análise estatística. A hepatotoxicidade induzida por INH + RIF resultou em elevação significativa das enzimas hepáticas séricas, incluindo aspartato aminotransferase (AST), alanina aminotransferase (ALT), fosfatase alcalina (ALP) e bilirrubina total, enquanto houve a diminuição do nível de albumina. O S. lycopersicum, na dose de 80 mg / kg, reduziu significativamente as enzimas hepáticas AST, ALT, ALP e bilirrubina, enquanto o nível de albumina aumentou de forma significativa. O tratamento não teve efeito significativo no peso corporal e hepático. A hepatotoxicidade induzida por drogas pode ser tratada de forma eficaz com S. lycopersicum na dose de 80 mg/kg.

Effects of Solanum lycopersicum L. (tomato) against isoniazid and rifampicin induced hepatotoxicity in wistar albino rats / Efeitos de Solanum lycopersicum L. (tomate) contra hepatotoxicidade induzida por isoniazida e rifampicina em ratos albinos wistar

Anti-tuberculosis drugs are reported to cause hepatotoxicity, which varies from asymptomatic rise of the hepatic enzymes. Hepatoprotective plants plays important role to protect liver. This study investigated the hepatoprotective potential of the Solanum lycopersicum in rats intoxicated with Isoniazid and Rifampicin (INH+RIF) to induce hepatotoxicity. Thirty wistar albino rats were divided into five groups of six animals each. Group 1 rats were kept control while groups II, III, IV and V were administered with INH+RIF (75+150 mg/kg) orally, for seven consecutive days. For treatment, rats in group III received silymarin while animals in group IV and V were provided with 40 mg/kg and 80 mg/kg of Solanum lycopersicum extract, respectively. On day 0 and 8th blood samples were collected for the analysis of hepatic biomarkers. The data were subjected to one-way ANOVA and Bonferroni's post hoc test for statistical analysis. Hepatotoxicity induced by INH+RIF resulted in significant elevation of serum hepatic enzymes including Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), Alkaline phosphatase (ALP), and total bilirubin while decreased the albumin level. The Solanum lycopersicum at dose of 80 mg/kg significantly reduced the hepatic enzymes AST, ALT, ALP and bilirubin while the albumin level was significantly increased. The treatment had non-significant effect on body and liver weight. Drug induced hepatotoxicity can be effectively treated with Solanum lycopersicum at 80 mg/kg dose.

As drogas antituberculose são relatadas como causadoras de hepatotoxicidade, ocasionando o aumento assintomático das enzimas hepáticas. As plantas hepatoprotetoras desempenham um papel importante na proteção do fígado. Este estudo investigou o potencial hepatoprotetor de Solanum lycopersicum em ratos que foram intoxicados com isoniazida e rifampicina (INH + RIF) para induzir hepatotoxicidade. Trinta ratos wistar albinos foram divididos em cinco grupos de seis animais cada. Os ratos do grupo 1 representaram o grupo controle, enquanto os ratos dos grupos II, III, IV e V receberam INH + RIF (75 + 150 mg/kg) por via oral, por sete dias consecutivos. Para o tratamento, os ratos do grupo III receberam silimarina, enquanto os animais do grupo IV e V receberam 40 mg/kg e 80 mg/kg de extrato de S. lycopersicum, respectivamente. Nos dias 0 e 8, foram coletadas amostras de sangue para análise de biomarcadores hepáticos. Os dados foram submetidos a teste unilateral (ANOVA) e post hoc de Bonferroni para análise estatística. A hepatotoxicidade induzida por INH + RIF resultou em elevação significativa das enzimas hepáticas séricas, incluindo aspartato aminotransferase (AST), alanina aminotransferase (ALT), fosfatase alcalina (ALP) e bilirrubina total, enquanto houve a diminuição do nível de albumina. O S. lycopersicum, na dose de 80 mg / kg, reduziu significativamente as enzimas hepáticas AST, ALT, ALP e bilirrubina, enquanto o nível de albumina aumentou de forma significativa. O tratamento não teve efeito significativo no peso corporal e hepático. A hepatotoxicidade induzida por drogas pode ser tratada de forma eficaz com S. lycopersicum na dose de 80 mg/kg.

Prognostic value of hematological parameters in older adult patients with acute coronary syndrome undergoing coronary intervention: a single centre prospective study / 老年心脏病学杂志（英文版）

BACKGROUND@#Cardiovascular disease is a significant contributor to the disease burden in geriatric patients. Underlying systemic inflammation is thought to be the cause of age-related changes in the bone marrow and a major risk factor for atherosclerosis. The purpose of the study was to assess the accuracy of these hematological biomarkers in predicting 30-day mortality in older patients with acute coronary syndrome (ACS).@*METHODS@#This was a prospective observational study of 601 older adult patients (age > 60 years) with ACS who underwent percutaneous coronary intervention over two years (2017-2019). The relationship between baseline hematological parameters and mortality was assessed during the 30-day follow-up. Logistic regression analysis and receiver operating characteristic curve analysis were done to evaluate for diagnostic accuracy of various hematological parameters.@*RESULTS@#The mean age of presentation was 77 ± 17 years. The mean neutrophil-lymphocyte ratio (NLR) value was 5.07 ± 4.90 and the mean platelet-lymphocyte ratio (PLR) value was 108.65 ± 85.82. On univariate analysis, total leucocyte count [odds ratio (OR) = 0.85, P = 0.021], hematocrit (OR = 0.91, P = 0.018), NLR (OR = 1.10, P = 0.001) and PLR (OR = 1.05, P = 0.001) were associated with mortality. On receiver operating characteristic curve analysis, NLR predicted mortality with 68.1% and PLR with 65.7% accuracy. On multivariate analysis, NLR (OR = 1.096, 95% CI: 1.006-1.15, P = 0.035) was an independent predictor of 30-day mortality.@*CONCLUSIONS@#For the risk classification of all elderly ACS patients, we highly advise using NLR rather than the total white blood cell count.

Selective Neck Dissection for Node-Positive Oral Cavity Squamous Cell Carcinoma: A Retrospective Cohort Study

Abstract Introduction Selective neck dissection inclinically node-negative neckisconsidered the standard of care for oral squamous cell carcinomas (SCCs). Controversy still prevailsinnode-positive disease regarding the extent of neck dissection. In our part of the world, comprehensive neck dissection is mostly considered to be the minimal optimal treatment for palpable neck disease. Objective To compare regional control and disease-specific survival between clinically node-positive and node-negative patients undergoing selective neck dissection for oral SCC. Methods This was a retrospective cohort study conducted in the department of ENT, Head and Neck surgery at a tertiary care hospital. All patients with biopsy-proven oral and lip SCC, with or without nodal disease, who underwent selective neck dissection between April 2006 and July 2015 were included in the study. Results During the study period, 111 patients with oral SCC underwent selective neck dissection, of whom 71 (62%) were clinically node-negative and 40 (38%) patients had clinically positive nodes in the neck. The mean follow-up was 16.62 months (standard deviation [SD]: 17.03). The overall regional control rates were 95 versus 96% for clinical negative versus positive nodes, respectively (p = 0.589). The disease-specific survival was 84.5% in the node negative group versus 82.5% in the node-positive group (p = 0.703). Conclusion Selective neck dissection in node-positive neck oral SCC has similar regional control rates when compared with node-negative neck SCC. The difference in disease-specific survival between the two groups is also not significant.

Laparoscopic versus open appendicectomy: a non-randomized comparative study

Background: Appendicectomy is one of the most common surgical procedures performed in emergency surgery. Despite this, there is still lack of consensus about the most appropriate technique for appendicectomy. In this longitudinal analysis, we aimed to compare the outcomes of laparoscopic appendicectomy (LA) and the conventional technique or open appendicectomy (OA) in the treatment of acute appendicitis.Methods: A non-randomized longitudinal comparative study was conducted in NKP Salve Institute of Medical Sciences and Lata Mangeshkar Hospital, Nagpur, India. From November 2017 to October 2019, 53 patients underwent OA and 59 underwent LA, making a total number of patients included in this study to be 112 (n). The two groups were compared for operative time, length of hospital stay, postoperative pain, post-operative ileus and complication rate.Results: Laparoscopic appendicectomy was associated with a shorter hospital stay (4.34±1.37 days in LA and 5.09±1.71 days in OA, p<0.01), with a lower post operative pain score [VAS] (2.93±0.80 in LA and 4.62±0.92 in OA, p<0.001). Operative time was shorter in the open group (42.70±12.05 min in OA and 43.39±16.59 in LA). Complications were lesser in the LA group with a significantly lower incidence of wound infection (3.4% in LA and 13.2% in OA).Conclusions: Laparoscopic approach is safe and efficient in appendicectomy and it provides clinically advantages over open method (shorter hospital stays, lower post op pain, early food tolerance, earlier return to work and lesser wound infection) against only marginally longer operative time.

Small interfering RNA for cancer treatment: overcoming hurdles in delivery

In many ways, cancer cells are different from healthy cells. A lot of tactical nano-based drug delivery systems are based on the difference between cancer and healthy cells. Currently, nanotechnology-based delivery systems are the most promising tool to deliver DNA-based products to cancer cells. This review aims to highlight the latest development in the lipids and polymeric nanocarrier for siRNA delivery to the cancer cells. It also provides the necessary information about siRNA development and its mechanism of action. Overall, this review gives us a clear picture of lipid and polymer-based drug delivery systems, which in the future could form the base to translate the basic siRNA biology into siRNA-based cancer therapies.

The changing trend of teleconsultations during COVID-19 era at a tertiary facility in Tanzania

Introduction: the current COVID-19 pandemic has occasioned the increased adoption of telemedicine. This study reports the uptake and trend of a new teleconsultation service in a Tanzanian hospital. Methods: this is a retrospective observational study that profiled requests for teleconsultations and uptake of the service between April 1, 2020, and June 30, 2020. Results: two hundred and eighteen telephone inquiries were received over the 3 months. One hundred and sixteen (53.2%) individuals followed through with the teleconsultations. Paediatric (38.8%) and Internal medicine (32.8%) were the subspecialties with the highest number of teleconsultations. In a frame of 3 months, teleconsultation uptake was highest in May and lowest in June. Conclusion: there was a steady rise and a rapid fall in requests and uptake of teleconsultation services over the period under evaluation. Lack of insurance coverage for teleconsultations was a significant barrier. We propose a re-education and reiteration of the benefits of telemedicine to all stakeholders. This is important for the current era and beyond

Sudden, new-onset aortic regurgitation during off pump coronary bypass surgery

During off pump coronary artery bypass grafting surgery, it is common to observe mitral or tricuspid regurgitation due to heart displacement. But it's very unusual to notice new onset aortic regurgitation in OPCABG.

Effect Of Synthetic Red Dye Orange Red And Natural Red Dye Alizarin On Biochemical And Hematological Parameters In Male Wistar Rats

Nowadays synthetic food dyes are mostly preferred than natural plant derived dyes due to low cost and intense coloration. In this study hematological and biochemical parameters were determined in male wistar rats after 30 days treatment with synthetic red dye orange red and natural plant derived red dye alizarin. 25 male wistar rats were divided into 5 groups with 5 animals per group. Group I rats were taken as control treated with normal rat diet and distilled water. Group II and III rats (experimental) were oral gavaged with 50 mg and 150 mg/kg body weight of alizarin dye. Group IV and V rats (experimental) were gavaged with 50 mg and 150 mg/kg body weight of orange red dye. Treatment of group V rats with 150 mg/kg body weight of orange red dye produce significant changes in RBC, Hb, Hct, MCH, serum aminotransferase enzymes and serum protein fraction. In comparison to this in group IV rats a significant change was observed only in Hb, serum aminotransferase enzymes and serum protein fraction when compared with control (group I) rats. However in group II and III alizarin treated rats no significant change was observed in different biochemical and hematological parameters relative to their respective control. In conclusion synthetic orange red dye proved to be more toxic than natural plant derived red dye alizarin.

Rational and irrational use of intra-venous infusions: a cross-sectional study among patients of a tertiary care hospital

Background: Intravenous infusions (IV) are a rapid mean of administering drugs. Hospitals are commonplace for their use, but at the same time they have many serious potential complications. This study aims to know the justified use of intravenous infusion among patients of a tertiary care hospital and awareness about its use.Methods: It was a cross-sectional study in which 249 subjects were conveniently studied. Nil per oral, severity of dehydration, vomiting, and diarrhoea was used as confirmatory criteria for using IV Infusions. Questionnaire with verbal consent was used to collect the data. Descriptive statistical analysis was applied to analyse the data and presented as means, frequencies and percentages in the form of tables and figure.Results: Total n249 (100%) subjects, n68 (27.3%) males and n181 (72.7%) females with average age was 24.05±14.21 years participated. Among n116 (46.6%) irrational users, females n76 (30.5%) were more then males n40 (16.1) with significant difference, p= 0.018. However, no significant difference was found among other variables (age groups, profession, education, awareness and rational or irrational use of IV infusion). Majority n249, n204 (81.9%) were not aware of the IV infusion medication error and doctors were most common unjustified prescribers of IV infusion, n105 (90.5%).Conclusions: The study concluded with the more prevalent irrational IV infusion use in our setup. Doctors appeared the dominant prescriber of irrational IV infusion. This statement is astonishing and must not be overlooked. Female gender, adult age, under-grade patients and students are more exposed to irrational IV infusion

Comparative Study of Levobupivacaine with Fentanyl Versus Ropivacaine with Fentanyl for Labor Analgesia

Effective pain relief is one of the important components of management of normal labor. Adequate pain relief is associated with reduction in maternal sympathetic activity and considerably decreased maternal anxiety level. Epidural analgesia is being increasingly used for this purpose. Many local anesthetic drugs are being used for providing epidural analgesia. We conducted this study to compare Ropivacaine and Levobupivacaine in terms of onset and duration of analgesia, motor involvement, hemodynamic effects and neonatal outcome. Methods: This was a prospective comparative study in which 100 patients presenting in spontaneous labour were included in this study on the basis of a predefined inclusion and exclusion criteria. Patients were divided into 2 groups on the basis of drug used. Group A patients received Ropivacaine along with fentanyl whereas group B patients received Levobupivacaine along with fentanyl. VAS score, Sensory and motor block and vital parameters were recorded before giving epidural and 5,15, 30 and 60 minutes and thereafter every hourly till delivery took place. Sensory block was assessed by pin prick sensation whereas motor block was assessed by modified bromage scale. Statistical analysis was done using SSPS 21 software and p value less than 0.05 was taken as statistically significant. Results: Parameters such as height, weight, body mass index, ASA grades, gravidity and duration of labor were found to be comparable in both the groups with no statistically significant difference in between 2 groups (P>0.05). Mode of delivery and conversion to LSCS was also similar in both the groups. Mean time for onset of analgesia was comparable in both the groups. The mean VAS scores in group A were found to be less as compared to group B during initial 1 hour after the bolus dose and the difference was found to be statistically significant (P<0.0001). After 1 hour the VAS scores were found to be comparable in both the groups with no statistically significant difference in the mean VAS scores of patients in both the groups (P>0.05). The need for top-up analgesia was found to be statistically significantly higher in group B as compared to group A (P=0.0277). The motor sparing was better in group A as compared to group B and the difference was found to be statistically significant (P=0.0026). Hemodynamics and neonatal outcome were found to be comparable in both the groups (P>0.05). Conclusion: Ropivacaine is a better local anesthetic drug as compared to Bupivacaine for labor analgesia. Its use is associated with better analgesic effect, superior motor sparing and less need for top up analgesic doses.

A Comparison of Fear Levels of Endodontic Treatment in Kashmiri Population

Dental fear is defined as the patient’s specific reaction towards stress related to dental treatment in which the stimulus is unknown. Aim of the study: To analyze the causative factor of fear during endodontic treatment. Methods: A simple random sampling technique was used for the study and a sample size of 141 patients with an age group of 12-65 years, attending outpatient the Department of Operative Dentistry. The survey done was based on 5 questionnaires before and during endodontic treatment. Results: The percentage of the females was 55% while the males were 45% of the patients attending dental office, 57% of the patients were found not afraid of attending dental office, 62% of the patients were found afraid of seeing the anesthetic needle, 59% of the patients were feeling pain during removal of pulp, 55% of the patients were found not afraid of sensation of file introduced in the canal, and 57% of the patients experienced unpleasant taste of endodontic materials. Conclusion: The present study concluded that seeing the anesthetic needle, feeling pain during removing the pulp and experiencing the unpleasant taste of endodontic materials were the most causative factors respectively for the fear of endodontic treatment.

A Survey of Endodontic Practice among the Dental Practitioners in Kashmir

To investigate and access the pattern of routine endodontic practice among the Dental practitioners in the Kashmir province. Methods: A survey was conducted in the form of a questionnaire and circulated among 334 dental practitioners through email. The response was collected, accumulated and analysed statistically. Results: A total of 178 (53%) dentists responded to the questionnaire that was emailed to them. 63% practitioners were males and only 37% were females. Only 10% of dental practitioners used isolation method as rubber dam. 56% of the dental practitioners were skilled in rotary endodontics. 70% of the practitioners used conventional ZOE sealer for obturation. Conclusion: Current qualitative endodontic guidelines in the established countries differ a lot as compared to the dental practise in this region. There is a shortage of endodontic equipments and materials in Government hospitals or public dental offices. Private dental offices are at much better positions. More of the innovations, latest concepts and techniques need to be incorporated into the dental practice of the dentists in Kashmir.

Analysis of NT-proBNP and uric acid due to left ventricle hypertrophy in the patients of aortic valve disease

Objective: To evaluate the concentration of N terminal proBNP [NT-proBNP] and partially the serum uric acid in the severe condition of aortic valve dysfunction for assessment of left ventricle hypertrophy

Methods: The study was conducted in the signal transduction lab department of biochemistry Quaid-I-Azam University, Islamabad from September 2013 to February 2017. NT-proBNP and serum uric acid were measured in one hundred patients of aortic valve dysfunction. The patients were divided into three main groups: 1] Aortic stenosis, 2] Aortic regurgitation, and 3] Aortic stenosis with Aortic regurgitation. The results were compared between disease and controls groups

Results: High level of plasma NT-proBNP was detected in all the three disease groups of aortic valve [stenosis, p<0.001], [regurgitation, p<0.001] and [stenosis with regurgitation, p<0.001]. In addition, non-significantly increased level of serum uric acid was also observed in left ventricle hypertrophy in all the three respective disease groups of aortic valve

Conclusion: Increased secretion of NT-proBNP during cardiac remodeling can be related to the severity of left ventricle hypertrophy due to aortic valve abnormality in all the disease groups of severe stenosis, severe regurgitation, and combine disease condition of severe stenosis and severe regurgitation. However, non-significant increase in uric acid concentration is also identified which may be due to one of the factors involved in left ventricle hypertrophy in all the three disease groups of aortic valve. The interaction of uric acid with NT-proBNP during cardiac remolding due to aortic valve dysfunction is still not clear

Comparative hepatoprotective effect of Nigella sativa pre- and post-treatment to rabbits

Synthetic drugs are associated with adverse side-effects and rapid increase in resistance to most of them inspires to evaluate plants for their therapeutic values. We have been aimed to suggest the medicinal use of Nigella sativa seed aqueous extract to minimize the severity of liver damage via its antioxidant properties and its role in maintenance of cell ion-homeostasis. Annoyances in serum levels of some antioxidants and trace metals in human hepatitis C infected patients were compared with that from acetaminophen-induced hepatotoxic rabbits. Serum analysis of human patients and that of hepatotoxic rabbits have exhibited the same trend of incidence of liver marker enzymes, antioxidant levels, and trace metal concentrations, except for the serum levels of cobalt. Significance of pre-/ or posttreatment of Nigella sativa to acetaminophen induced-hepatotoxic rabbit has also evaluated. NS post-treatment to rabbits has been found effective in normalizing the levels [P<0.001] of serum liver markers; especially the ALP levels, and the antioxidants; with significant effect on the serum catalase levels. However, NS pre-treatment has shown its role [P<0.001] in maintaining the serum nickel and cobalt concentrations. Therefore, we suggest the use of Nigella sativa seeds as pre-/ or post-treatment therapy, and also as supplement to the normal medications of liver infection to normalize the status of cell antioxidants and trace metal concentrations

A curious case of raised gradient across mitral bioprosthetic valve

High Doppler valve gradient is generally suggestive of valve thrombosis. However, it should be corroborated with the finding of restricted leaflet movement to confirm the diagnosis. In the present case, abnormally high gradient was not associated with limited leaflet movements or any valve thrombus.

Areca Nut - An Unusual Cause Of Small Intestinal Obstruction

Ingested foreign bodies are commonly encountered in clinical practice, especially in children. Till now, no case has been reported in the literature where a small intestinal obstruction was produced as a result of foreign body (areca nut) ingestion. We report a case of a 30-year-old female clinically presented as an acute intestinal obstruction of 4 days duration. Her plain X-ray abdomen showed multiple small intestinal fluid levels. Abdominal ultrasound showed dilated loops of small intestine. Contrast-enhanced computed tomography abdomen showed an intraluminal non-enhancing lesion near ileocecal junction. Exploratory laparotomy revealed 3 cm×2.5 cm× 2.5 cm rounded foreign body (swollen areca nut) causing an intestinal obstruction which was removed by enterotomy. There was no ileal stricture or diverticulum noted. Post-operative period was uneventful

Acute Limb Ischemia Due to Cardiac Thromboembolismin a Young Patient without Myocardial Infarction or Cardiomyopathy

Acute limb ischemia secondary to systemic arterial embolism from left ventricular thrombus is a rare life threatening emergency. Peripheral arterial thrombosis superimposed on an atherosclerotic disease or thromboembolism from cardiac or aortic source are the two most common causes of acute limb ischemia. We present a case of a young healthy female who had recurrent admissions with acute lower extremity ischemia secondary to embolism from intra cardiac thrombus diagnosed by bedside doppler and computed angiogram, managed by surgical thromboembolectomy and discharge on anticoagulation.

Laparoscopic Management Of Gastric Outlet Obstruction Due To Gastric Lipoma: A Case Report.

A gastric lipoma is a rare entity and accounts for 2–3% of all benign gastric lesions. It is a diagnostic challenge. We present a case of a 35-year-old male who presented with intermittent attacks of pain in abdomen, vomiting, and dyspepsia. Upper gastrointestinal (GI) endoscopy showed a polypoidal lesion in the antrum prolapsing into the duodenum. Contrast-enhanced computed tomography abdomen showed a 5 cm × 3 cm × 3 cm, oval, smooth fat density lesion in the posterior wall of the antrum near the pylorus confirming the diagnosis of submucosal gastric lipoma with gastric outlet obstruction. Laparoscopic gastrostomy with removal of submucosal lipoma was done with uneventful post-operative recovery. The patient gained 10 kg weight after 18 months of follow-up without any GI symptoms. In conclusion, gastric lipomas are rare benign tumors of the stomach which may mimic malignancy.