One case of Lynch type II syndrome / 대한산부인과학회지

Lynch syndrome is also called Hereditary nonpolyposis colorectal cancer (HNPCC). It is characterized by a risk of colorectal cancer and other cancers of the endometrium, ovary, stomach, small intestine etc. The increased risk is due to inherited mutations that impaired DNA mismatch repair. Two to three percentage of colon cancer is caused by Lynch syndrome. A family history of colon cancer occurs at a young age. We experienced one case of Lynch syndrome who had had stomach cancer, endometrial cancer and colon cancer recently. Hence we report this case with a brief review of literature.

Apoptosis Induced by Contact Lens Wearing in Rabbit Cornea

The purpose of this study was to determine the role of apoptosis in the contact lens-worn cornea and the pathophysiologic influence of the contact lens to the rabbit corneal tissue, We had 4 experimental groups; soft contact-worn, RGP contact-worn, mechanically scraped and ormal control groups. The corneas were prepared for routine H & E staining and apoptosis evaluation. Keratocyte and epithelia cell morphology of the cornea were examined in each group using light microscopy. Nuclear DNA fragmentation was detected with the TUNEL assay for 3`-hydroxy DNA ends. The apoptosis assay demonstrated: (a) both the normal cornea and the contact lens-worn cornea exhibited no apoptosis, (b) silight degree of apoptosis was corneal apoptosis detected n deratocytes of the soft contact lensworn cornea, and (c) the anterior stromal keratocytes were found to be frequently undergoing apoptotic change in the scraped cornea. Theses findings suggest that the possible hypoxia induced by soft contact lens-wearing may have a role in apoptosis of anterior stromal keratocytes. To be clinically significant, we need more evaluations and long term studies of apoptosis in contact lens-worn cornea.

Primary Conjunctival Malignant Lymphoma of Mucosa-Associated Lymophoid Tissue

Malignant lymphomas arising in mucosa-associated lymphoid tissue(MALT) account for a significant proportion of extranodal lymphomas. Included among this group of tumors are lymphomas of the gastrointestinal tract, salivary gland, lung and thyroid. But their conjunctival involvements are rare, less than 1.5% of all conjunctival tumors. The authors examined the 51-year-old man who showed the primary conjunctival malignant lymphoma of MALT. It involved the inferior fornix and medial canthal area in his left eye without systemic involvement. We confirmed it by immunohistochemical studies of biopsied tissue, also including computed tomography, sonography, thyroid and bone scan. The patient was successfully treated with radiotherapy. We report this case with a recent review of the ophthalmic literature.