RESUMEN
Obesity is one of the major risk factors for many diseases such as cardiovascular disease and diabetes. Although a few studies have been shown the pharmacological properties of Peganum harmala, there is no data on the anti-obesity effect of this plant. This study was designed to investigate the effect of the hydroalcoholic extract of Peganum harmala seed on the weight and blood biochemical parameters in male wistar rats. Fifty male Wistar rats were categorized into 5 groups: Negative control group [standard diet]; positive control group [high-fat diet with 4% of fat]; treatment groups [high-fat diet + hydroalcoholic extract of Peganum harmala at 200 and 400 mg/kg/day and high-fat diet + Orlistat at 200 mg/kg/day]. Extracts and orlistat were administrated by gavage for 8 weeks, and levels of serum glucose, triglycerides, cholesterol, high density lipoprotein [HDL] and liver enzymes were measured by routine laboratory kits. Our findings demonstrate that this extract reduced weight in the group that received high-fat diet, at both doses [P<0.05]. This extract also significantly decreased the levels of serum glucose, triglycerides, and cholesterol and increased HDL in the group that received high-fat diet [P<0.05]; however it had no effect on reduction of liver enzymes. Our data suggest that the hydroalcoholic extract of Peganum harmala has beneficial effects on controlling body weight in animals fed with a high-fat diet and it also significantly improves biochemical parameters in animals fed with a high-fat diet
RESUMEN
Objective: to study the effect of CIDR on oestrous synchronization and comparison of twining percentage by using eCG and handing diet and their interaction
Design: completely randomized design
Statistical analysis: use of SPSS statistical program for parameter data and X2 and Man- Witny test for non- parameter data
Animals: a total of 69 ewes and 6 rams of Zandi breed
Procedure: sixty-nine Zandi ewes within 2-5 years old and weighting 47.9 [k5.6] Kg, were divided into 3 groups [group I fed in the pasture and two other groups were fed in their pens]. In order to synchronize oestrous cycle, all ewes [in 3 groups] were treated for 13 days with a controlled internal drug-releasing device [CIDR]. On the following day after removing CIDRs, ewes in groups 1 and 2 received an injection of 400 ILT eCG Two Zandi rams were then introduced to each group
Results: the results of the present study indicated that oestrus was induced within 36-48h post CIDR withdrawal in 100, 87 and 96 percentage of ewes in groups 1, 2 and 3 respectively and this differences were not significant. The percentage of parturition was 91, 83 and 87 in groups 1, 2 and 3 respectively and differences were not significant. The percentage of twining [based on ewes lambing] was significantly [P<0.05] lower in the group 3, comparing to groups 1 and 2 [29,37 and 15 in groups 1,2 and 3 respectively]. Male and single born lambs was heavier than female and twinborn lambs [4.2,4.2 and 3.7, 3.5 respectively], but differences were not significant. However, these differences within each group were significant [P<0.05]. The effect weight of dam on the born weight was also significant [P<0.05]
Conclusion: the result of this study indicated that using of synthetic hormone caused length period of pamuition decreased. Also difference of age and weight of lambs are lower. Besides cueing the synthetic hormones caused that percentage of twining increased