RESUMEN
Background and Purpose: Noise, in high intensity, is one of the major physical stressors. The aim of this study was to determine the effect of stress of threshold limit value of noise with shrill and bass frequencies on antioxidation and lipid peroxidation variations of liver tissue of rabbit
Methods and Materials: This experimental study was carried out on 18 male white New Zealand rabbits at Tarbiat Modarres University in 2004. Rabbits were randomly divided into three groups: Control Group [unexposed to noise], Group 2 exposed to noise [85 dB SPL,< 250-3540Hz, 8 h/day, 96 h] and Group 3 exposed to noise [3540Hz-20kHz, 85 dB SPL, 8 h/day for 96h, 12 days]. The obtained data were analyzed in SPSS. One-way ANOVA and post hoc Tukey test were used for comparing means across the groups; differences at P<0.05 were considered statistically significant
Results: The findings indicated that Malondialdehyde [MDA] levels were 5.5, 5.54, and 5.71 in the groups 1, 2, and 3 respectively, and that the glutathione level was 0.131 g per micromol liver tissue across three groups. It was also found that the differences were not statistically significant [P=0<0.05]
Conclusion: According to the findings of the present study, despite limited variation in Malondialdehyde [MDA] levels induced by noise with 85dBA frequency, it does not induce significant changes in levels of Malondialdehyde [MDA] and glutathione in the liver tissue of rabbits