Therapeutic drug-induced liver injury in liver biopsies

35 patients admitted to Mansoura University Hospital with the clinical picture of hepatitis were selected for the present investigation after being asked carefully for history of drug intake and examined clinically. Stool examinations were negative for Bilharzia and other parasites. Serological tests were negative for hepatitis surface antigen. Ture cut needle biopsy for liver was done for all of these patients and stained with various stains. These were one patient with history of halothain intake, 10 with history of intake of oral contraceptive, 2 with history of chlorpromazine and 20 with history of phenyl-butazone and 20 with history of isoniazid. Histologically a spectrum of lesions was recognized as a result of liver injury by these drugs. The produced lesions were categorized as follows: 1-lesion resembling viral hepatitis. 2-Cholestasis with inflammation and liver cell damage. 3-Pure cholestasis. The drugs causing each of these lesions and their differential diagnosis specially from viral hepatitis were discussed

Histopathological of lymphoma like lymphadenopathy

60 lymph nodes were collected and diagnosed as pseudolymphoma they were grouped into 4 groups, follicular pattern forming 19 cases, sinous pattern 16 cases, diffuse pattern 15 cases and mixed pattern 11 cases. The histopathology of each variety was described, the follicular variety was the dominating one in children the causes of this pattern and its differentiation from follicular lymphoma was discussed. In the group of sinous pattern, a special attention was paid to malignant histocytosis and the various types of metastatic carcinoma and the differentiation of these two conditions. The causes and differential diagnosis of diffuse and mixed pattern was also discussed