Effect of hydroalcoholic extract of dodoneae viscosa on pain and anxiety in male rats

Background: Pain is caused by acute or potential tissue damage. Anxiety disorders are common psychiatric disorders in humans that are experienced in threatening situations. Herbal drugs have fewer side effects than chemical drugs

Objective: Evoulution of Hydroalcoholic Extract of Dodoneae viscosa on Pain and Anxiety in Male Rats

Methods: in this study 35 Wister male rats randomly divided in to 5 groups: 1] control group, 2] sham group that received normal saline, 3-5] groups received 100,200,400 mg/kg extract for 10 days by gavages respectively. Pain was tested by formalin test. Anxiety was tested by open filed. Results Dotoneae viscosa extract had a dose-dependent anti-nociceptive effect on chronic pains caused by the formalin injection [P<0.001]. Also check anti-anxiety effects in open box test indicated significant difference in dose of 100, 200 mg/kg extract [effective dose] in Number of passages from the central lines [P<0.001],[P<0.01], Time spend in central line [P<0.001], starch [P<0.001], Grooming [P<0.01], [P<0.05]. 400mg/kg had no effect

Results: According to the presented data, the concentration and amount of silymarin in different extracts was compared. The extract obtained from ground seeds with methanol was able to reach the most amount of silymarin while the highest concentration of silymarin was obtained from the extract of ground pericarp with ethanol 80%

Conclusion: The results indicated that Dodoneae viscosa extract as an antioxidant and anti-inflammatory agent is effective in the treatment of inflammatory diseases and relieving long-term pain such as opioid drugs

[Effects of adentonsillectomy on pulmonary function parameters]

Adenotonsillar hypertrophy is a common finding among children which in untreated cases may result in serious cardiopulmonary problems. There are limited studies about the effect of adenotonsillectomy on pulmonary function parameters. Does adenotonsillectomy affect on pulmonary function? This study is performed to reveal this purpose. In a pre- and post-treatment clinical trial on 39 children between 6-13 years old with indication of adenotonsillectomy due to obstructive respiratory symptoms [because of prominent hypertrophy of tonsils and/or adenoid tissue], 5 main Spirometric parameters weere measured before and 2 months after adenotonsillectomy with a standard method and data were analyzed by paired t-test. 39 children [56% male and 44% female] with a mean age of 8.95 +/- 1.93 were evaluated. 4 main Spirometric parameters increased: FEV1/FVC from 89.H12.7 to 97 +/- 4.6, FEV0.5/FVC from 70.9 +/- 15.5 to 81.U11.8, FEV25-75 from 1.9 +/- 0.6 to 2.2 +/- 0.7, MEF50 from 2 +/- 0.6 to 2.4 +/- 0.7 and all the improvement was statistically significant [P<0.0001]. There was no statistically significant change in FEV1/ PEFR index. Due to obvious changes of 4 main Spirometric parameters, it can be deduced that adenotonsillectomy is of effective roles in improvement of pulmonary function

[Effects of adenotonsillectomy on pulmonary arterial pressure]

There are several studies which have shown that adenotonsillar hypertrophy can cause airway obstruction, chronic alveolar hypoventilation and even may lead to severe cardiopulmonary complications like pulmonary artery hypertension. The aim of this study was to evaluate the effects of adenotonsillectomy on pulmonary arterial pressure in children with hypertrophic tonsils and adenoids. fourty children [21 males, 19 females] aged between 4 and 14 [mean 7/9 +/- 2/3] years with a diagnosis of upper airway obstruction due to hypetrophied tonsils and adenoids were included in our study. Pulmonary arterial pressure was measured by Doppler echocardiography both preoperatively, and 6 weeks after operation. Preoperative pulmonary arterial pressure [PAP] was 26/1 +/- 3/9 mmHg and postoperative PAP was 25/9 +/- 5 mmHg. Although in two cases out of three ones who had raised preoperative PAP, adenotonsillectomy resulted in decreasing the pressure, but there was no statistically significant difference between pre-operative and post-operative echocardiographic findings. It seems that whilst increasing of pulmomary arterial pressure [owing to Adenotonsillar hypertrophy], adenotonsillectomy can be of beneficial outcomes in decreasing this pressure

[Comparison of efficacy of iontophoresis with tap water and iontophoresis with atropine solution in treatment of palmoplantar hyperhidrosis in Loqman Hospital during 2006]

Background: focal hyperhidrosis is not rare, affecting nearly 3% of the population. This condition is often socially and professionally debilitating, leading to significant quality of life impairment. Hence, its treatment is an issue of importance. To determine the comparative efficacy of tap water iontophoresis to iontophoresis with atropine

Materials and Methods: we undertook a single-blinded right-left clinical trial in 16 patients with palmoplantar hyperhidrosis attending to dermatology clinic of Loqman Hospital during 2006. We compared the efficacy and the duration of symptom relief following iontophoresis with atropine to iontophoresis with tap water according to both objective [Iodine Test] and subjective [patients' judgment] criteria

Results: therapeutic efficacy was 81.25% after 5 weeks and 100% after 10 weeks of iontophoresis. Following treatment with tap water iontophoresis and atropine iontophoresis, patients reported similar improvement in two hands. Atropine iontophoresis was superior to tap water only after five sessions; however it was not statistically significant [P> 0.05]

Conclusion: we postulate that the similar efficacy of atropine iontophoresis when compared with tap water iontophoresis relates to mechanism of action of iontophoresis which is not affected by atropine, additionally

Prevalence of HCV infection and related risk factors among patients on hemodialysis in Qazvin

Background: Hepatitis C virus [HCV] infection is common among patients undergoing hemodialysis, and chronic liver disease is an important cause of mortality in this population

Objective: This study was conducted in 2000 to investigate the prevalence of HCV infection and associated risk factors among patients on hemodialysis in Qazvin

Methods: In this case series study 68 patients on hemodialysis in Qazvin were selected randomly and all were checked for anti-HCV antibodies, using ELISA 2[nd] and confirmed using RIBA 2[nd]

Findings: 16 patients [23.9%] were infected. Patients' sex, educational level, history of upper GI endoscopy and previous renal transplantation had no impact on HCV infection rate, but blood transfusion was an important risk factor for HCV infection [P=0.02]. The more units transfused, the greater rate of HCV infection was reported [P=0.003]. Moreover,the mean time of hemodialysis was significantly longer in HCV Ab positive cases [P=0.007]

Conclusion: It seems that early transplantation and avoidance of blood transfusion as much as possible- forexample by using erithropoietin are the two most important practical interventions to reduce HCV exposure rate in patients on hemodialysis