RESUMEN
Inflammatory bowel disease [IBD] is a chronic gastrointestinal inflammatory disease of unknown etiology. Nutrition has been proposed as an important factor in etiology of IBD. The aim of this study was to compare dietary intake of antioxidants and serum levels of alpha -tocopherol and vitamin C in IBD patients with that of healthy subjects. Twenty-six IBD and twenty-eight sex and age matched healthy subjects were selected as the case and control groups from gastroenterology and other wards respectively, during the fall and winter of 2005. Subjects' serum vitamin C and alpha-tocopherol levels were analyzed using the HPLC method. Semi-quantitative food frequency questionnaires were completed by all subjects during interviews. There was no significant difference in serum levels of vitamin C and alpha -tocopherol between the two study groups. Intakes of whole grain bread and fresh vegetables in healthy subjects were 2.5 and 1.5 times higher than those of patients, respectively [p<0.05]. Although patients consumed fewer cups of tea daily [p<0.05], no significant difference was seen in the intakes of other dietary antioxidant sources between the two groups. Results of this study indicated that although there was no significant difference between vitamin C and alpha -tocopherol serum levels in the both groups, dietary intake of the main antioxidant sources in IBD patients was lower than healthy matched subjects. More advanced studies with higher number of subjects are needed to explore the antioxidant status in such patients