[Comparative dissolution study of drugs using protein hdrolysates]

Kneaded mixtures as well as physical mixtures, of an acidic drug, indomethacin, a basic drug vincamine, and a neutral drug, prednisolone, with gelatin and casein hydrolysates were prepared. Their in vitro dissolution profiles were examined. The dissolution of drugs from the kneaded mixtures was significantly increased compared to the drugs alone as well as their physical mixtures. This increase was most prominent for the acidic drug indomethacin. The casein and gelatin hydrolysates enhanced the dissolution of the three drugs by improving the wettability of the drug particles. Solubility also contributes to the enhancement of dissolution of indomethacin and prednisolone. Buffering was an additional reason in case of indomethacin

Effect of some physiological changes on the binding of tenoxicam to human serum albumin

The influence of some physiological changes due to age or disease on the binding of tenoxicam to human serum albumin [HSA] was studied. Increasing HSA concentration within the range of 0.04% to 0.4% decreased the binding parameters, K1, n1 and n2. The presence of fatty acids decreased the affinity of HSA binding to tenoxicam at low protein concentrations. Urea as well as glucose increased the binding affinity of HSA to tenoxicam. The values of n1 and n2 were not significantly changed except when glucose was elevated to 500 mg/dL causing n1 and n2 to be nearly halved. Binding of tenoxicam to HSA increased as pH increased within the tested values of 6.8, 7.4 and 8. Consequently, tenoxicam was preferably bound by B rather than N form of HSA

Formulation and pharmaceutical evaluation of sulindac suspensions

Sulindac has been introduced in suspension dosage form which has suited its low aqueous solubility, its use in the fields of pediatrics and geriatrics, and its requirement of dose flexibility. A wettability study showed that 0.05% tween 20 was the wetting agent of choice. Controlled flocculation was adopted to prepare the flocculated suspensions. 32 deflocculated as well as 20 flocculated suspension formulations were prepared using different classes of suspending agents. The parameters used for evaluation were the sedimentation volume ratio [Vu/Vo], easiness of sediment redispersibility, clarity and color of supernatant, the time of the suspension has remained dispersed after being shaken, degree of flocculation, pH stability, conductivity, specific gravity, rheological properties, and dissolution. The deflocculated formula of choice was formula 18 containing 0.5% xanthan gum. The best flocculated suspension was formula 19 containing 10% glycerin, 10% propylene glycol, and 40% sorbitol as density modifiers

Comparative dissolution study of drugs using protein hydrolysates

Kneaded mixtures as well as physical mixtures, of an acidic drug, indomethacin, a basic drug, vincamine, and a neutral drug, prednisolone, with gelatin and casein hydrolysates were prepared. Their in-vitro dissolution profiles were examined. The dissolution of drugs from the kneaded mixtures was significantly increased compared to the drugs alone as well as their physical mixtures. This increase was most prominent for the acidic drug indomethacin. The casein and gelatin hydrolysates enhanced the dissolution of the three drugs by improving the wettability of the drug particles. Solubility also contributed to the enhancement of dissolution of indomethacin and prednisolone. Buffering was an additional reason in case of indomethacin