RESUMEN
Weanling 60 female mice were treated by at the dose of 375 mg/kg b.w/day of tartrazine till sexual maturity to gestation and lactation period. Body weight absolute and relative weight of the thymus gland and spleen were recorded. Also percentage of Thy 1.2[+] and PNA[+] in thymus and Thy 1.2[+], Ig[+] in spleen respectively during gestation days [15, 17, 19] and weekly during lactation period. The total body weight, absolute and relative weight of the thymus and spleen recorded a significant decrease during gestation. An increase in body weight was recorded as well no significant difference in absolute or relative weight was observed in lactation period. On the other hand, an significant decrease well be observed in PNA[+], Thy 1.2[+] and Ig[+], in both two organs