RESUMEN
Certain polyene macrolides were developed from different actinomycetes at Research and Development of Hindustan Antibiotics Limited. These antibiotics were screened for the antifungal activity against various plant pathogens. IC50 and MIC of each of the antibiotic against the plant pathogens was found out and is being reported.
Asunto(s)
Actinomycetaceae/metabolismo , Antibacterianos/farmacología , Antifúngicos/farmacología , India , Macrólidos , Pruebas de Sensibilidad Microbiana , Hongos Mitospóricos/efectos de los fármacos , Enfermedades de las Plantas/microbiología , Polienos/farmacologíaRESUMEN
A Streptomyces sp. CS-14 producing antifungal and antibacterial antibiotics has been isolated and characterized. The characterization of mycelial bound antibiotic revealed the presence of a hexaene polyene macrolide whereas filtrate bound antibiotic belonged to aminoglycoside group. Both the antibiotics showed very good antimicrobial activities in vitro.
Asunto(s)
Antibacterianos/biosíntesis , Bacterias/efectos de los fármacos , Pruebas de Sensibilidad Microbiana , Streptomyces/clasificaciónRESUMEN
The production of amyloglucosidase by a new variety of Aspergillus candidus was studied on various natural carbon and nitrogen nutrient sources. Jowar starch and peanut meal were found to be the best nutrient sources of carbon and nitrogen respectively. The maximum enzyme productivity was observed at pH 6.5 and temperature 32 degrees C. Sodium fluoride was found to inhibit enzyme amyloglucosidase to an extent of 85%. Addition of trace metals viz. Zinc, copper and potassium in the medium impaired the production of the enzyme. A four fold purification of the enzyme was achieved with ammonium sulphate precipitation. The partially purified enzyme gave 84% conversion efficiency of starch to glucose in 10% starch solution without the addition of liquefying enzyme.