RESUMEN
The effect of fresh stem juice extract of Costus afer on cytohistomorphology of the kidney in aspirin-treated Wistarrats was evaluated. 25 rats weighing 150–180 g used for the study were divided into five groups with five rats in eachgroup. Group 1 served as control while Group 2 was administered 150 mg/kg bw of aspirin daily for 28 days, Group 3received 67.08 mg/kg bw of the extract of C. afer for 28 days, Group 4 was administered 150 mg/kg of aspirin and67.08 mg/kg of the extract for 28 days while Group 5 was administered 150 mg/kg of aspirin for 14 days and then67.08 mg/kg of the extract for another 14 days. Kidneys were harvested for histological studies. The results revealedthat Group 1 showed normal histological features, Group 2 showed tubular necrosis, collapsed urinary space, anddistorted glomerulus, Group 3 presented near normal features, Group 4 showed enlarged urinary space, inflamedtubular cells and reduced podocytes in the glomerulus compared to Group 2, and Group 5 revealed regeneration ofcellular features already destroyed by aspirin. In conclusion, fresh stem juice extract of C. afer has ameliorative andprotective potentials on nephrotoxicity of aspirin in albino Wistar rats.